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000155622 1001_ $$aElezkurtaj, Sefer$$b0
000155622 245__ $$aCauses of death and comorbidities in hospitalized patients with COVID-19.
000155622 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2021
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000155622 520__ $$aInfection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has been associated with more than two million deaths worldwide. Patients of higher age and with preexisting chronic health conditions are at an increased risk of fatal disease outcome. However, detailed information on causes of death and the contribution of pre-existing health conditions to death yet is missing, which can be reliably established by autopsy only. We performed full body autopsies on 26 patients that had died after SARS-CoV-2 infection and COVID-19 at the Charité University Hospital Berlin, Germany, or at associated teaching hospitals. We systematically evaluated causes of death and pre-existing health conditions. Additionally, clinical records and death certificates were evaluated. We report findings on causes of death and comorbidities of 26 decedents that had clinically presented with severe COVID-19. We found that septic shock and multi organ failure was the most common immediate cause of death, often due to suppurative pulmonary infection. Respiratory failure due to diffuse alveolar damage presented as immediate cause of death in fewer cases. Several comorbidities, such as hypertension, ischemic heart disease, and obesity were present in the vast majority of patients. Our findings reveal that causes of death were directly related to COVID-19 in the majority of decedents, while they appear not to be an immediate result of preexisting health conditions and comorbidities. We therefore suggest that the majority of patients had died of COVID-19 with only contributory implications of preexisting health conditions to the mechanism of death.
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000155622 650_2 $$2MeSH$$aAdult
000155622 650_2 $$2MeSH$$aAged
000155622 650_2 $$2MeSH$$aAged, 80 and over
000155622 650_2 $$2MeSH$$aAutopsy
000155622 650_2 $$2MeSH$$aBerlin: epidemiology
000155622 650_2 $$2MeSH$$aCOVID-19: complications
000155622 650_2 $$2MeSH$$aCOVID-19: mortality
000155622 650_2 $$2MeSH$$aCOVID-19: therapy
000155622 650_2 $$2MeSH$$aCOVID-19: virology
000155622 650_2 $$2MeSH$$aCause of Death
000155622 650_2 $$2MeSH$$aComorbidity
000155622 650_2 $$2MeSH$$aFemale
000155622 650_2 $$2MeSH$$aHospital Mortality
000155622 650_2 $$2MeSH$$aHospitals, Teaching: statistics & numerical data
000155622 650_2 $$2MeSH$$aHumans
000155622 650_2 $$2MeSH$$aHypertension: epidemiology
000155622 650_2 $$2MeSH$$aMale
000155622 650_2 $$2MeSH$$aMiddle Aged
000155622 650_2 $$2MeSH$$aMultiple Organ Failure: mortality
000155622 650_2 $$2MeSH$$aMultiple Organ Failure: virology
000155622 650_2 $$2MeSH$$aMyocardial Ischemia: epidemiology
000155622 650_2 $$2MeSH$$aObesity: epidemiology
000155622 650_2 $$2MeSH$$aProspective Studies
000155622 650_2 $$2MeSH$$aSARS-CoV-2: isolation & purification
000155622 650_2 $$2MeSH$$aShock, Septic: mortality
000155622 650_2 $$2MeSH$$aShock, Septic: virology
000155622 7001_ $$aGreuel, Selina$$b1
000155622 7001_ $$aIhlow, Jana$$b2
000155622 7001_ $$aMichaelis, Edward Georg$$b3
000155622 7001_ $$aBischoff, Philip$$b4
000155622 7001_ $$aKunze, Catarina Alisa$$b5
000155622 7001_ $$aSinn, Bruno Valentin$$b6
000155622 7001_ $$aGerhold, Manuela$$b7
000155622 7001_ $$aHauptmann, Kathrin$$b8
000155622 7001_ $$aIngold-Heppner, Barbara$$b9
000155622 7001_ $$aMiller, Florian$$b10
000155622 7001_ $$aHerbst, Hermann$$b11
000155622 7001_ $$0P:(DE-2719)9001090$$aCorman, Victor$$b12$$udzne
000155622 7001_ $$aMartin, Hubert$$b13
000155622 7001_ $$aRadbruch, Helena$$b14
000155622 7001_ $$0P:(DE-2719)2812386$$aHeppner, Frank L$$b15$$udzne
000155622 7001_ $$aHorst, David$$b16
000155622 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-021-82862-5$$gVol. 11, no. 1, p. 4263$$n1$$p4263$$tScientific reports$$v11$$x2045-2322$$y2021
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