Home > Publications Database > Causes of death and comorbidities in hospitalized patients with COVID-19. > print

001     155622
005     20240223115102.0
024 7 _ |a 10.1038/s41598-021-82862-5
|2 doi
024 7 _ |a pmid:33608563
|2 pmid
024 7 _ |a pmc:PMC7895917
|2 pmc
024 7 _ |a altmetric:100593393
|2 altmetric
037 _ _ |a DZNE-2021-00790
041 _ _ |a English
082 _ _ |a 600
100 1 _ |a Elezkurtaj, Sefer
|b 0
245 _ _ |a Causes of death and comorbidities in hospitalized patients with COVID-19.
260 _ _ |a [London]
|c 2021
|b Macmillan Publishers Limited, part of Springer Nature
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1708602931_31172
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Infection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has been associated with more than two million deaths worldwide. Patients of higher age and with preexisting chronic health conditions are at an increased risk of fatal disease outcome. However, detailed information on causes of death and the contribution of pre-existing health conditions to death yet is missing, which can be reliably established by autopsy only. We performed full body autopsies on 26 patients that had died after SARS-CoV-2 infection and COVID-19 at the Charité University Hospital Berlin, Germany, or at associated teaching hospitals. We systematically evaluated causes of death and pre-existing health conditions. Additionally, clinical records and death certificates were evaluated. We report findings on causes of death and comorbidities of 26 decedents that had clinically presented with severe COVID-19. We found that septic shock and multi organ failure was the most common immediate cause of death, often due to suppurative pulmonary infection. Respiratory failure due to diffuse alveolar damage presented as immediate cause of death in fewer cases. Several comorbidities, such as hypertension, ischemic heart disease, and obesity were present in the vast majority of patients. Our findings reveal that causes of death were directly related to COVID-19 in the majority of decedents, while they appear not to be an immediate result of preexisting health conditions and comorbidities. We therefore suggest that the majority of patients had died of COVID-19 with only contributory implications of preexisting health conditions to the mechanism of death.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Autopsy
|2 MeSH
650 _ 2 |a Berlin: epidemiology
|2 MeSH
650 _ 2 |a COVID-19: complications
|2 MeSH
650 _ 2 |a COVID-19: mortality
|2 MeSH
650 _ 2 |a COVID-19: therapy
|2 MeSH
650 _ 2 |a COVID-19: virology
|2 MeSH
650 _ 2 |a Cause of Death
|2 MeSH
650 _ 2 |a Comorbidity
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Hospital Mortality
|2 MeSH
650 _ 2 |a Hospitals, Teaching: statistics & numerical data
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Hypertension: epidemiology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Multiple Organ Failure: mortality
|2 MeSH
650 _ 2 |a Multiple Organ Failure: virology
|2 MeSH
650 _ 2 |a Myocardial Ischemia: epidemiology
|2 MeSH
650 _ 2 |a Obesity: epidemiology
|2 MeSH
650 _ 2 |a Prospective Studies
|2 MeSH
650 _ 2 |a SARS-CoV-2: isolation & purification
|2 MeSH
650 _ 2 |a Shock, Septic: mortality
|2 MeSH
650 _ 2 |a Shock, Septic: virology
|2 MeSH
700 1 _ |a Greuel, Selina
|b 1
700 1 _ |a Ihlow, Jana
|b 2
700 1 _ |a Michaelis, Edward Georg
|b 3
700 1 _ |a Bischoff, Philip
|b 4
700 1 _ |a Kunze, Catarina Alisa
|b 5
700 1 _ |a Sinn, Bruno Valentin
|b 6
700 1 _ |a Gerhold, Manuela
|b 7
700 1 _ |a Hauptmann, Kathrin
|b 8
700 1 _ |a Ingold-Heppner, Barbara
|b 9
700 1 _ |a Miller, Florian
|b 10
700 1 _ |a Herbst, Hermann
|b 11
700 1 _ |a Corman, Victor
|0 P:(DE-2719)9001090
|b 12
|u dzne
700 1 _ |a Martin, Hubert
|b 13
700 1 _ |a Radbruch, Helena
|b 14
700 1 _ |a Heppner, Frank L
|0 P:(DE-2719)2812386
|b 15
|u dzne
700 1 _ |a Horst, David
|b 16
773 _ _ |a 10.1038/s41598-021-82862-5
|g Vol. 11, no. 1, p. 4263
|0 PERI:(DE-600)2615211-3
|n 1
|p 4263
|t Scientific reports
|v 11
|y 2021
|x 2045-2322
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/155622/files/DZNE-2021-00790.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/155622/files/DZNE-2021-00790.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:155622
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 12
|6 P:(DE-2719)9001090
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 15
|6 P:(DE-2719)2812386
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
913 0 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2021
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-03-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-03-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2023-03-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2023-03-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
|d 2023-03-30
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b SCI REP-UK : 2021
|d 2023-03-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2022-08-08T09:38:07Z
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2022-08-08T09:38:07Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-03-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-03-30
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
|d 2023-03-30
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2023-03-30
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
|d 2023-03-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-02-03
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2021-02-03
920 1 _ |0 I:(DE-2719)1810007
|k AG Heppner
|l Neuroimmunology
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1810007
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21