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000155629 0247_ $$2doi$$a10.1523/ENEURO.0354-20.2020
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000155629 041__ $$aEnglish
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000155629 1001_ $$aGrosser, Sabine$$b0
000155629 245__ $$aParvalbumin Interneurons Are Differentially Connected to Principal Cells in Inhibitory Feedback Microcircuits along the Dorsoventral Axis of the Medial Entorhinal Cortex.
000155629 260__ $$aWashington, DC$$bSoc.$$c2021
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000155629 520__ $$aThe medial entorhinal cortex (mEC) shows a high degree of spatial tuning, predominantly grid cell activity, which is reliant on robust, dynamic inhibition provided by local interneurons (INs). In fact, feedback inhibitory microcircuits involving fast-spiking parvalbumin (PV) basket cells (BCs) are believed to contribute dominantly to the emergence of grid cell firing in principal cells (PrCs). However, the strength of PV BC-mediated inhibition onto PrCs is not uniform in this region, but high in the dorsal and weak in the ventral mEC. This is in good correlation with divergent grid field sizes, but the underlying morphologic and physiological mechanisms remain unknown. In this study, we examined PV BCs in layer (L)2/3 of the mEC characterizing their intrinsic physiology, morphology and synaptic connectivity in the juvenile rat. We show that while intrinsic physiology and morphology are broadly similar over the dorsoventral axis, PV BCs form more connections onto local PrCs in the dorsal mEC, independent of target cell type. In turn, the major PrC subtypes, pyramidal cell (PC) and stellate cell (SC), form connections onto PV BCs with lower, but equal probability. These data thus identify inhibitory connectivity as source of the gradient of inhibition, plausibly explaining divergent grid field formation along this dorsoventral axis of the mEC.
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000155629 650_7 $$2Other$$aGABAergic interneurons
000155629 650_7 $$2Other$$aentorhinal cortex
000155629 650_7 $$2Other$$afeedback inhibition
000155629 650_7 $$2Other$$amicrocircuit
000155629 650_7 $$2Other$$amorphology
000155629 650_7 $$2Other$$asynapse
000155629 650_7 $$2NLM Chemicals$$aParvalbumins
000155629 650_2 $$2MeSH$$aAction Potentials
000155629 650_2 $$2MeSH$$aAnimals
000155629 650_2 $$2MeSH$$aEntorhinal Cortex: metabolism
000155629 650_2 $$2MeSH$$aFeedback
000155629 650_2 $$2MeSH$$aInterneurons: metabolism
000155629 650_2 $$2MeSH$$aParvalbumins: metabolism
000155629 650_2 $$2MeSH$$aPyramidal Cells: metabolism
000155629 650_2 $$2MeSH$$aRats
000155629 7001_ $$aBarreda, Federico J$$b1
000155629 7001_ $$0P:(DE-2719)2810901$$aBeed, Prateep Sanker$$b2$$udzne
000155629 7001_ $$0P:(DE-2719)2810725$$aSchmitz, Dietmar$$b3$$udzne
000155629 7001_ $$00000-0003-1980-9873$$aBooker, Sam A$$b4
000155629 7001_ $$00000-0003-3214-2233$$aVida, Imre$$b5
000155629 773__ $$0PERI:(DE-600)2800598-3$$a10.1523/ENEURO.0354-20.2020$$gVol. 8, no. 1, p. ENEURO.0354-20.2020 -$$n1$$pENEURO.0354-20.2020$$teNeuro$$v8$$x2373-2822$$y2021
000155629 8564_ $$uhttps://www.eneuro.org/content/8/1/ENEURO.0354-20.2020
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