% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Grosser:155629,
      author       = {Grosser, Sabine and Barreda, Federico J and Beed, Prateep
                      Sanker and Schmitz, Dietmar and Booker, Sam A and Vida,
                      Imre},
      title        = {{P}arvalbumin {I}nterneurons {A}re {D}ifferentially
                      {C}onnected to {P}rincipal {C}ells in {I}nhibitory
                      {F}eedback {M}icrocircuits along the {D}orsoventral {A}xis
                      of the {M}edial {E}ntorhinal {C}ortex.},
      journal      = {eNeuro},
      volume       = {8},
      number       = {1},
      issn         = {2373-2822},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {DZNE-2021-00797},
      pages        = {ENEURO.0354-20.2020},
      year         = {2021},
      abstract     = {The medial entorhinal cortex (mEC) shows a high degree of
                      spatial tuning, predominantly grid cell activity, which is
                      reliant on robust, dynamic inhibition provided by local
                      interneurons (INs). In fact, feedback inhibitory
                      microcircuits involving fast-spiking parvalbumin (PV) basket
                      cells (BCs) are believed to contribute dominantly to the
                      emergence of grid cell firing in principal cells (PrCs).
                      However, the strength of PV BC-mediated inhibition onto PrCs
                      is not uniform in this region, but high in the dorsal and
                      weak in the ventral mEC. This is in good correlation with
                      divergent grid field sizes, but the underlying morphologic
                      and physiological mechanisms remain unknown. In this study,
                      we examined PV BCs in layer (L)2/3 of the mEC characterizing
                      their intrinsic physiology, morphology and synaptic
                      connectivity in the juvenile rat. We show that while
                      intrinsic physiology and morphology are broadly similar over
                      the dorsoventral axis, PV BCs form more connections onto
                      local PrCs in the dorsal mEC, independent of target cell
                      type. In turn, the major PrC subtypes, pyramidal cell (PC)
                      and stellate cell (SC), form connections onto PV BCs with
                      lower, but equal probability. These data thus identify
                      inhibitory connectivity as source of the gradient of
                      inhibition, plausibly explaining divergent grid field
                      formation along this dorsoventral axis of the mEC.},
      keywords     = {Action Potentials / Animals / Entorhinal Cortex: metabolism
                      / Feedback / Interneurons: metabolism / Parvalbumins:
                      metabolism / Pyramidal Cells: metabolism / Rats / GABAergic
                      interneurons (Other) / entorhinal cortex (Other) / feedback
                      inhibition (Other) / microcircuit (Other) / morphology
                      (Other) / synapse (Other) / Parvalbumins (NLM Chemicals)},
      cin          = {AG Schmitz},
      ddc          = {610},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33531369},
      pmc          = {pmc:PMC8114875},
      doi          = {10.1523/ENEURO.0354-20.2020},
      url          = {https://pub.dzne.de/record/155629},
}