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@ARTICLE{Snderby:155631,
      author       = {Sønderby, Ida E and Ching, Christopher R K and
                      Thomopoulos, Sophia I and van der Meer, Dennis and Sun,
                      Daqiang and Villalon-Reina, Julio E and Agartz, Ingrid and
                      Amunts, Katrin and Arango, Celso and Armstrong, Nicola J and
                      Ayesa-Arriola, Rosa and Bakker, Geor and Bassett, Anne S and
                      Boomsma, Dorret I and Bülow, Robin and Butcher, Nancy J and
                      Calhoun, Vince D and Caspers, Svenja and Chow, Eva W C and
                      Cichon, Sven and Ciufolini, Simone and Craig, Michael C and
                      Crespo-Facorro, Benedicto and Cunningham, Adam C and Dale,
                      Anders M and Dazzan, Paola and de Zubicaray, Greig I and
                      Djurovic, Srdjan and Doherty, Joanne L and Donohoe, Gary and
                      Draganski, Bogdan and Durdle, Courtney A and Ehrlich, Stefan
                      and Emanuel, Beverly S and Espeseth, Thomas and Fisher,
                      Simon E and Ge, Tian and Glahn, David C and Grabe, Hans J
                      and Gur, Raquel E and Gutman, Boris A and Haavik, Jan and
                      Håberg, Asta K and Hansen, Laura A and Hashimoto, Ryota and
                      Hibar, Derrek P and Holmes, Avram J and Hottenga, Jouke-Jan
                      and Hulshoff Pol, Hilleke E and Jalbrzikowski, Maria and
                      Knowles, Emma E M and Kushan, Leila and Linden, David E J
                      and Liu, Jingyu and Lundervold, Astri J and Martin-Brevet,
                      Sandra and Martínez, Kenia and Mather, Karen A and Mathias,
                      Samuel R and McDonald-McGinn, Donna M and McRae, Allan F and
                      Medland, Sarah E and Moberget, Torgeir and Modenato, Claudia
                      and Monereo Sánchez, Jennifer and Moreau, Clara A and
                      Mühleisen, Thomas W and Paus, Tomas and Pausova, Zdenka and
                      Prieto, Carlos and Ragothaman, Anjanibhargavi and Reinbold,
                      Céline S and Reis Marques, Tiago and Repetto, Gabriela M
                      and Reymond, Alexandre and Roalf, David R and
                      Rodriguez-Herreros, Borja and Rucker, James J and Sachdev,
                      Perminder S and Schmitt, James E and Schofield, Peter R and
                      Silva, Ana I and Stefansson, Hreinn and Stein, Dan J and
                      Tamnes, Christian K and Tordesillas-Gutiérrez, Diana and
                      Ulfarsson, Magnus O and Vajdi, Ariana and van 't Ent, Dennis
                      and van den Bree, Marianne B M and Vassos, Evangelos and
                      Vázquez-Bourgon, Javier and Vila-Rodriguez, Fidel and
                      Walters, G Bragi and Wen, Wei and Westlye, Lars T and
                      Wittfeld, Katharina and Zackai, Elaine H and Stefánsson,
                      Kári and Jacquemont, Sebastien and Thompson, Paul M and
                      Bearden, Carrie E and Andreassen, Ole A and Bernard, Manon
                      and Blackburn, Nicholas B and Bøen, Rune and de Geus, Eco
                      and de Zwarte, Sonja M C and Forti, Marta Di and Frei,
                      Oleksandr and Fukunaga, Masaki and Hehir-Kwa, Jayne Y and
                      Hillegers, Manon H J and Hoffmann, Per and Homuth, Georg and
                      Jahanshad, Neda and Koops, Sanne and Kumar, Kuldeep and
                      Kikuchi, Masataka and Le Hellard, Stephanie and Leu, Costin
                      and Murray, Robin M and Naerland, Terje and Nyberg, Lars and
                      Ophoff, Roel A and Pike, G Bruce and Sando, Sigrid B and
                      Shin, Jean and Shumskaya, Elena and Sisodiya, Sanjay M and
                      Steen, Vidar M and Teumer, Alexander and Uhlmann, Anne and
                      Wright, Margaret J and Antshel, Kevin M and Campbell, Linda
                      E and Crossley, Nicolas A and Crowley, T Blaine and Daly,
                      Eileen and Fiksinski, Ania M and Forsyth, Jennifer K and
                      Fremont, Wanda and Goodrich-Hunsaker, Naomi J and
                      Gudbrandsen, Maria and Jonas, Rachel K and Kates, Wendy R
                      and Lin, Amy and McCabe, Kathryn L and Moss, Hayley and
                      Murphy, Declan G and Murphy, Kieran C and Owen, Michael J
                      and Ruparel, Kosha and Simon, Tony J and van Amelsvoort,
                      Therese and Vorstman, Jacob A S},
      collaboration = {Group, ENIGMA-CNV Working and 2 Deletion Syndrome Working
                      Group, ENIGMA 22q11.},
      title        = {{E}ffects of copy number variations on brain structure and
                      risk for psychiatric illness: {L}arge-scale studies from the
                      {ENIGMA} working groups on {CNV}s.},
      journal      = {Human brain mapping},
      volume       = {43},
      number       = {1},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2021-00799},
      pages        = {300-328},
      year         = {2022},
      note         = {(CC BY)},
      abstract     = {The Enhancing NeuroImaging Genetics through Meta-Analysis
                      copy number variant (ENIGMA-CNV) and 22q11.2 Deletion
                      Syndrome Working Groups (22q-ENIGMA WGs) were created to
                      gain insight into the involvement of genetic factors in
                      human brain development and related cognitive, psychiatric
                      and behavioral manifestations. To that end, the ENIGMA-CNV
                      WG has collated CNV and magnetic resonance imaging (MRI)
                      data from ~49,000 individuals across 38 global research
                      sites, yielding one of the largest studies to date on the
                      effects of CNVs on brain structures in the general
                      population. The 22q-ENIGMA WG includes 12 international
                      research centers that assessed over 533 individuals with a
                      confirmed 22q11.2 deletion syndrome, 40 with 22q11.2
                      duplications, and 333 typically developing controls,
                      creating the largest-ever 22q11.2 CNV neuroimaging data set.
                      In this review, we outline the ENIGMA infrastructure and
                      procedures for multi-site analysis of CNVs and MRI data. So
                      far, ENIGMA has identified effects of the 22q11.2, 16p11.2
                      distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and
                      cortical brain structures. Each CNV is associated with
                      differences in cognitive, neurodevelopmental and
                      neuropsychiatric traits, with characteristic patterns of
                      brain structural abnormalities. Evidence of gene-dosage
                      effects on distinct brain regions also emerged, providing
                      further insight into genotype-phenotype relationships. Taken
                      together, these results offer a more comprehensive picture
                      of molecular mechanisms involved in typical and atypical
                      brain development. This 'genotype-first' approach also
                      contributes to our understanding of the etiopathogenesis of
                      brain disorders. Finally, we outline future directions to
                      better understand effects of CNVs on brain structure and
                      behavior.},
      subtyp        = {Review Article},
      keywords     = {Brain: diagnostic imaging / Brain: growth $\&$ development
                      / Brain: pathology / DNA Copy Number Variations / Humans /
                      Magnetic Resonance Imaging / Mental Disorders: diagnostic
                      imaging / Mental Disorders: genetics / Mental Disorders:
                      pathology / Multicenter Studies as Topic /
                      Neurodevelopmental Disorders: diagnostic imaging /
                      Neurodevelopmental Disorders: genetics / Neurodevelopmental
                      Disorders: pathology / Neuroimaging / brain structural
                      imaging (Other) / copy number variant (Other) / diffusion
                      tensor imaging (Other) / evolution (Other) / genetics-first
                      approach (Other) / neurodevelopmental disorders (Other) /
                      psychiatric disorders (Other)},
      cin          = {AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8675420},
      pubmed       = {pmid:33615640},
      doi          = {10.1002/hbm.25354},
      url          = {https://pub.dzne.de/record/155631},
}