Home > Publications Database > Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. > print

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024 7 _ |a pmc:PMC8675431
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024 7 _ |a 10.1002/hbm.25364
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024 7 _ |a pmid:33595143
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024 7 _ |a 1065-9471
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024 7 _ |a 1097-0193
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037 _ _ |a DZNE-2021-00806
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Frangou, Sophia
|0 0000-0002-3210-6470
|b 0
|e Corresponding author
245 _ _ |a Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.
260 _ _ |a New York, NY
|c 2022
|b Wiley-Liss
336 7 _ |a article
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336 7 _ |a Journal Article
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520 _ _ |a Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
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650 _ 7 |a aging
|2 Other
650 _ 7 |a cortical thickness
|2 Other
650 _ 7 |a development
|2 Other
650 _ 7 |a trajectories
|2 Other
650 _ 2 |a Adolescent
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Cerebral Cortex: anatomy & histology
|2 MeSH
650 _ 2 |a Cerebral Cortex: diagnostic imaging
|2 MeSH
650 _ 2 |a Child
|2 MeSH
650 _ 2 |a Child, Preschool
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650 _ 2 |a Cross-Sectional Studies
|2 MeSH
650 _ 2 |a Female
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650 _ 2 |a Human Development: physiology
|2 MeSH
650 _ 2 |a Humans
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650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neuroimaging
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650 _ 2 |a Young Adult
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