000155671 001__ 155671
000155671 005__ 20221128161133.0
000155671 020__ $$a978-3-030-51139-5 (print)
000155671 020__ $$a978-3-030-51140-1 (electronic)
000155671 0247_ $$2doi$$a10.1007/978-3-030-51140-1_16
000155671 0247_ $$2pmid$$apmid:33433880
000155671 0247_ $$2ISSN$$a0065-2598
000155671 0247_ $$2ISSN$$a2214-8019
000155671 0247_ $$2altmetric$$aaltmetric:97590326
000155671 037__ $$aDZNE-2021-00839
000155671 041__ $$aEnglish
000155671 082__ $$a570
000155671 1001_ $$0P:(DE-2719)2810728$$aHeutink, Peter$$b0$$eFirst author$$udzne
000155671 245__ $$aA Multi-omics Data Resource for Frontotemporal Dementia Research.
000155671 260__ $$aCham$$bSpringer International Publishing$$c2021
000155671 29510 $$aFrontotemporal Dementias / Ghetti, Bernardino (Editor) ; Cham : Springer International Publishing, 2021, Chapter 16 ; ISSN: 0065-2598=2214-8019 ; ISBN: 978-3-030-51139-5=978-3-030-51140-1 ; doi:10.1007/978-3-030-51140-1
000155671 300__ $$a269 - 282
000155671 3367_ $$2ORCID$$aBOOK_CHAPTER
000155671 3367_ $$07$$2EndNote$$aBook Section
000155671 3367_ $$2DRIVER$$abookPart
000155671 3367_ $$2BibTeX$$aINBOOK
000155671 3367_ $$2DataCite$$aOutput Types/Book chapter
000155671 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1630493573_17165
000155671 4900_ $$aAdvances in Experimental Medicine and Biology$$v1281
000155671 520__ $$aFrontotemporal dementia (FTD) is a neurodegenerative disease with high heritability. Almost half of all familial cases are caused by mutations in one of the three genes MAPT, GRN and C9orf72. Even though major advances in FTD research have been achieved during the last decades, it is not yet fully understood how mutations in these diverse genes lead to the disease. To improve our understanding of FTD, the Risk and Modifying Factors in Frontotemporal Dementia (RiMod-FTD) consortium has created an FTD-specific multi-omics data resource. Using multiple omics technologies on post-mortem brain tissue from patients with mutations in GRN, MAPT or C9orf72 and healthy controls, the resource aims to provide a comprehensive cellular profile of FTD. Furthermore, brain tissue from multiple mouse models and induced pluripotent stem cells (iPSC)-derived neuronal cultures were profiled with similar multi-omics technologies to make up for the shortcomings of post-mortem brain tissue. All data are publicly available to all researchers, and ongoing efforts aim to increase the available datasets and to improve their accessibility. The RiMod-FTD resource represents a uniquely valuable dataset for the field of FTD research, which we hope will accelerate the scientific progress in the field.
000155671 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
000155671 588__ $$aDataset connected to CrossRef Book Series, PubMed, , Journals: pub.dzne.de
000155671 650_7 $$2NLM Chemicals$$aC9orf72 Protein
000155671 650_7 $$2NLM Chemicals$$aC9orf72 protein, human
000155671 650_7 $$2NLM Chemicals$$atau Proteins
000155671 650_2 $$2MeSH$$aAnimals
000155671 650_2 $$2MeSH$$aC9orf72 Protein: genetics
000155671 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000155671 650_2 $$2MeSH$$aHumans
000155671 650_2 $$2MeSH$$aMice
000155671 650_2 $$2MeSH$$aMutation
000155671 650_2 $$2MeSH$$aNeurodegenerative Diseases
000155671 650_2 $$2MeSH$$aPick Disease of the Brain
000155671 650_2 $$2MeSH$$atau Proteins: genetics
000155671 7001_ $$0P:(DE-2719)2812499$$aMenden, Kevin$$b1$$udzne
000155671 7001_ $$0P:(DE-2719)2812478$$aDalmia, Anupriya$$b2$$eLast author$$udzne
000155671 773__ $$a10.1007/978-3-030-51140-1_16
000155671 909CO $$ooai:pub.dzne.de:155671$$pVDB
000155671 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810728$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000155671 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812499$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000155671 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812478$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000155671 9130_ $$0G:(DE-HGF)POF3-341$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vMolecular Signaling$$x0
000155671 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x0
000155671 9141_ $$y2021
000155671 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)1120$$2StatID$$aDBCoverage$$bBIOSIS Reviews Reports And Meetings$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bADV EXP MED BIOL : 2019$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-01-28
000155671 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-01-28
000155671 9201_ $$0I:(DE-2719)1210002$$kAG Heutink 1$$lGenome Biology of Neurodegenerative Diseases$$x0
000155671 980__ $$acontb
000155671 980__ $$aVDB
000155671 980__ $$aI:(DE-2719)1210002
000155671 980__ $$aUNRESTRICTED