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001     155671
005     20221128161133.0
020 _ _ |a 978-3-030-51139-5 (print)
020 _ _ |a 978-3-030-51140-1 (electronic)
024 7 _ |a 10.1007/978-3-030-51140-1_16
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024 7 _ |a pmid:33433880
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024 7 _ |a 0065-2598
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024 7 _ |a 2214-8019
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037 _ _ |a DZNE-2021-00839
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Heutink, Peter
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245 _ _ |a A Multi-omics Data Resource for Frontotemporal Dementia Research.
260 _ _ |a Cham
|c 2021
|b Springer International Publishing
295 1 0 |a Frontotemporal Dementias / Ghetti, Bernardino (Editor) ; Cham : Springer International Publishing, 2021, Chapter 16 ; ISSN: 0065-2598=2214-8019 ; ISBN: 978-3-030-51139-5=978-3-030-51140-1 ; doi:10.1007/978-3-030-51140-1
300 _ _ |a 269 - 282
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490 0 _ |a Advances in Experimental Medicine and Biology
|v 1281
520 _ _ |a Frontotemporal dementia (FTD) is a neurodegenerative disease with high heritability. Almost half of all familial cases are caused by mutations in one of the three genes MAPT, GRN and C9orf72. Even though major advances in FTD research have been achieved during the last decades, it is not yet fully understood how mutations in these diverse genes lead to the disease. To improve our understanding of FTD, the Risk and Modifying Factors in Frontotemporal Dementia (RiMod-FTD) consortium has created an FTD-specific multi-omics data resource. Using multiple omics technologies on post-mortem brain tissue from patients with mutations in GRN, MAPT or C9orf72 and healthy controls, the resource aims to provide a comprehensive cellular profile of FTD. Furthermore, brain tissue from multiple mouse models and induced pluripotent stem cells (iPSC)-derived neuronal cultures were profiled with similar multi-omics technologies to make up for the shortcomings of post-mortem brain tissue. All data are publicly available to all researchers, and ongoing efforts aim to increase the available datasets and to improve their accessibility. The RiMod-FTD resource represents a uniquely valuable dataset for the field of FTD research, which we hope will accelerate the scientific progress in the field.
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650 _ 7 |a C9orf72 Protein
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650 _ 7 |a C9orf72 protein, human
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a C9orf72 Protein: genetics
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: genetics
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mutation
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases
|2 MeSH
650 _ 2 |a Pick Disease of the Brain
|2 MeSH
650 _ 2 |a tau Proteins: genetics
|2 MeSH
700 1 _ |a Menden, Kevin
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700 1 _ |a Dalmia, Anupriya
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773 _ _ |a 10.1007/978-3-030-51140-1_16
909 C O |o oai:pub.dzne.de:155671
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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914 1 _ |y 2021
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