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000155678 0247_ $$2doi$$a10.1016/j.visres.2020.10.004
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000155678 037__ $$aDZNE-2021-00846
000155678 041__ $$aEnglish
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000155678 1001_ $$0P:(DE-2719)2812615$$aCoors, Annabell$$b0$$udzne
000155678 245__ $$aStrong age but weak sex effects in eye movement performance in the general adult population: Evidence from the Rhineland Study.
000155678 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
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000155678 520__ $$aAssessing physiological changes that occur with healthy ageing is prerequisite for understanding pathophysiological age-related changes. Eye movements are studied as biomarkers for pathological changes because they are altered in patients with neurodegenerative disorders. However, there is a lack of data from large samples assessing age-related physiological changes and sex differences in oculomotor performance. Thus, we assessed and quantified cross-sectional relations of age and sex with oculomotor performance in the general population. We report results from the first 4,000 participants (aged 30-95 years) of the Rhineland Study, a community-based prospective cohort study in Bonn, Germany. Participants completed fixation, smooth pursuit, prosaccade and antisaccade tasks. We quantified associations of age and sex with oculomotor outcomes using multivariable linear regression models. Performance in 12 out of 18 oculomotor measures declined with increasing age. No differences between age groups were observed in five antisaccade outcomes (amplitude-adjusted and unadjusted peak velocity, amplitude gain, spatial error and percentage of corrected errors) and for blink rate during fixation. Small sex differences occurred in smooth pursuit velocity gain (men have higher gain) and blink rate during fixation (men blink less). We conclude that performance declines with age in two thirds of oculomotor outcomes but that there was no evidence of sex differences in eye movement performance except for two outcomes. Since the percentage of corrected antisaccade errors was not associated with age but is known to be affected by pathological cognitive decline, it represents a promising candidate preclinical biomarker of neurodegeneration.
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000155678 650_7 $$2Other$$aAging
000155678 650_7 $$2Other$$aBiomarker
000155678 650_7 $$2Other$$aEpidemiology
000155678 650_7 $$2Other$$aNeurodegenerative diseases
000155678 650_7 $$2Other$$aSaccade
000155678 650_7 $$2Other$$aSex differences
000155678 650_2 $$2MeSH$$aAdult
000155678 650_2 $$2MeSH$$aCross-Sectional Studies
000155678 650_2 $$2MeSH$$aEye Movements
000155678 650_2 $$2MeSH$$aFemale
000155678 650_2 $$2MeSH$$aHumans
000155678 650_2 $$2MeSH$$aMale
000155678 650_2 $$2MeSH$$aProspective Studies
000155678 650_2 $$2MeSH$$aPursuit, Smooth
000155678 650_2 $$2MeSH$$aSaccades
000155678 693__ $$0EXP:(DE-2719)Rhineland Study-20190321$$5EXP:(DE-2719)Rhineland Study-20190321$$eRhineland Study / Bonn$$x0
000155678 7001_ $$0P:(DE-2719)2811270$$aMerten, Natascha$$b1$$udzne
000155678 7001_ $$0P:(DE-2719)2812417$$aWard, David D$$b2$$udzne
000155678 7001_ $$0P:(DE-2719)2811245$$aSchmid, Matthias$$b3$$udzne
000155678 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique M B$$b4$$udzne
000155678 7001_ $$aEttinger, Ulrich$$b5
000155678 773__ $$0PERI:(DE-600)2011974-4$$a10.1016/j.visres.2020.10.004$$gVol. 178, p. 124 - 133$$p124 - 133$$tVision research$$v178$$x0042-6989$$y2021
000155678 8564_ $$uhttps://www.sciencedirect.com/science/article/pii/S0042698920301735?via%3Dihub
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