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000155682 0247_ $$2doi$$a10.1080/09553002.2021.1857455
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000155682 037__ $$aDZNE-2021-00850
000155682 041__ $$aEnglish
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000155682 1001_ $$00000-0002-9168-9733$$aUng, Marie-Claire$$b0
000155682 245__ $$aDose-dependent long-term effects of a single radiation event on behaviour and glial cells.
000155682 260__ $$aAbingdon$$bInforma Healthcare$$c2021
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000155682 520__ $$aThe increasing use of low-dose ionizing radiation in medicine requires a systematic study of its long-term effects on the brain, behaviour and its possible association with neurodegenerative disease vulnerability. Therefore, we analysed the long-term effects of a single low-dose irradiation exposure at 10 weeks of age compared to medium and higher doses on locomotor, emotion-related and sensorimotor behaviour in mice as well as on hippocampal glial cell populations.We determined the influence of radiation dose (0, 0.063, 0.125 or 0.5 Gy), time post-irradiation (4, 12 and 18 months p.i.), sex and genotype (wild type versus mice with Ercc2 DNA repair gene point mutation) on behaviour.The high dose (0.5 Gy) had early-onset adverse effects at 4 months p.i. on sensorimotor recruitment and late-onset negative locomotor effects at 12 and 18 months p.i. Notably, the low dose (0.063 Gy) produced no early effects but subtle late-onset (18 months) protective effects on sensorimotor recruitment and exploratory behaviour. Quantification and morphological characterization of the microglial and the astrocytic cells of the dentate gyrus 24 months p.i. indicated heightened immune activity after high dose irradiation (0.125 and 0.5 Gy) while conversely, low dose (0.063 Gy) induced more neuroprotective features.This is one of the first studies demonstrating such long-term and late-onset effects on brain and behaviour after a single radiation event in adulthood.
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000155682 650_7 $$2Other$$aIrradiation
000155682 650_7 $$2Other$$aastrocytes
000155682 650_7 $$2Other$$abehavior
000155682 650_7 $$2Other$$abrain
000155682 650_7 $$2Other$$amice
000155682 650_7 $$2Other$$amicroglia
000155682 650_7 $$0EC 3.6.4.12$$2NLM Chemicals$$aXeroderma Pigmentosum Group D Protein
000155682 650_7 $$0EC 5.99.-$$2NLM Chemicals$$aErcc2 protein, mouse
000155682 650_2 $$2MeSH$$aAnimals
000155682 650_2 $$2MeSH$$aBehavior, Animal: radiation effects
000155682 650_2 $$2MeSH$$aDose-Response Relationship, Radiation
000155682 650_2 $$2MeSH$$aFemale
000155682 650_2 $$2MeSH$$aHippocampus: radiation effects
000155682 650_2 $$2MeSH$$aMale
000155682 650_2 $$2MeSH$$aMice
000155682 650_2 $$2MeSH$$aMice, Inbred C3H
000155682 650_2 $$2MeSH$$aMice, Inbred C57BL
000155682 650_2 $$2MeSH$$aMotor Activity: radiation effects
000155682 650_2 $$2MeSH$$aNeuroglia: radiation effects
000155682 650_2 $$2MeSH$$aWhole-Body Irradiation
000155682 650_2 $$2MeSH$$aXeroderma Pigmentosum Group D Protein: genetics
000155682 7001_ $$00000-0003-4880-7076$$aGarrett, Lillian$$b1
000155682 7001_ $$00000-0002-8040-4464$$aDalke, Claudia$$b2
000155682 7001_ $$aLeitner, Valentin$$b3
000155682 7001_ $$aDragosa, Daniel$$b4
000155682 7001_ $$00000-0002-9684-6216$$aHladik, Daniela$$b5
000155682 7001_ $$aNeff, Frauke$$b6
000155682 7001_ $$aWagner, Florian$$b7
000155682 7001_ $$00000-0002-5411-9213$$aZitzelsberger, Horst$$b8
000155682 7001_ $$00000-0002-4281-4905$$aMiller, Gregor$$b9
000155682 7001_ $$0P:(DE-2719)9000920$$ade Angelis, Martin Hrabě$$b10$$udzne
000155682 7001_ $$aRößler, Ute$$b11
000155682 7001_ $$00000-0002-4566-6506$$aVogt Weisenhorn, Daniela$$b12
000155682 7001_ $$0P:(DE-2719)2000028$$aWurst, Wolfgang$$b13$$udzne
000155682 7001_ $$00000-0003-0298-9660$$aGraw, Jochen$$b14
000155682 7001_ $$00000-0003-4878-5241$$aHölter, Sabine M$$b15$$eCorresponding author
000155682 773__ $$0PERI:(DE-600)3065-X$$a10.1080/09553002.2021.1857455$$gVol. 97, no. 2, p. 156 - 169$$n2$$p156 - 169$$tInternational journal of radiation biology$$v97$$x1362-3095$$y2021
000155682 8564_ $$uhttps://www.tandfonline.com/doi/full/10.1080/09553002.2021.1857455
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