TY  - JOUR
AU  - Ung, Marie-Claire
AU  - Garrett, Lillian
AU  - Dalke, Claudia
AU  - Leitner, Valentin
AU  - Dragosa, Daniel
AU  - Hladik, Daniela
AU  - Neff, Frauke
AU  - Wagner, Florian
AU  - Zitzelsberger, Horst
AU  - Miller, Gregor
AU  - de Angelis, Martin Hrabě
AU  - Rößler, Ute
AU  - Vogt Weisenhorn, Daniela
AU  - Wurst, Wolfgang
AU  - Graw, Jochen
AU  - Hölter, Sabine M
TI  - Dose-dependent long-term effects of a single radiation event on behaviour and glial cells.
JO  - International journal of radiation biology
VL  - 97
IS  - 2
SN  - 1362-3095
CY  - Abingdon
PB  - Informa Healthcare
M1  - DZNE-2021-00850
SP  - 156 - 169
PY  - 2021
N1  - ISSN 1362-3095 not unique: **2 hits**.
AB  - The increasing use of low-dose ionizing radiation in medicine requires a systematic study of its long-term effects on the brain, behaviour and its possible association with neurodegenerative disease vulnerability. Therefore, we analysed the long-term effects of a single low-dose irradiation exposure at 10 weeks of age compared to medium and higher doses on locomotor, emotion-related and sensorimotor behaviour in mice as well as on hippocampal glial cell populations.We determined the influence of radiation dose (0, 0.063, 0.125 or 0.5 Gy), time post-irradiation (4, 12 and 18 months p.i.), sex and genotype (wild type versus mice with Ercc2 DNA repair gene point mutation) on behaviour.The high dose (0.5 Gy) had early-onset adverse effects at 4 months p.i. on sensorimotor recruitment and late-onset negative locomotor effects at 12 and 18 months p.i. Notably, the low dose (0.063 Gy) produced no early effects but subtle late-onset (18 months) protective effects on sensorimotor recruitment and exploratory behaviour. Quantification and morphological characterization of the microglial and the astrocytic cells of the dentate gyrus 24 months p.i. indicated heightened immune activity after high dose irradiation (0.125 and 0.5 Gy) while conversely, low dose (0.063 Gy) induced more neuroprotective features.This is one of the first studies demonstrating such long-term and late-onset effects on brain and behaviour after a single radiation event in adulthood.
KW  - Animals
KW  - Behavior, Animal: radiation effects
KW  - Dose-Response Relationship, Radiation
KW  - Female
KW  - Hippocampus: radiation effects
KW  - Male
KW  - Mice
KW  - Mice, Inbred C3H
KW  - Mice, Inbred C57BL
KW  - Motor Activity: radiation effects
KW  - Neuroglia: radiation effects
KW  - Whole-Body Irradiation
KW  - Xeroderma Pigmentosum Group D Protein: genetics
KW  - Irradiation (Other)
KW  - astrocytes (Other)
KW  - behavior (Other)
KW  - brain (Other)
KW  - mice (Other)
KW  - microglia (Other)
KW  - Xeroderma Pigmentosum Group D Protein (NLM Chemicals)
KW  - Ercc2 protein, mouse (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:33264576
DO  - DOI:10.1080/09553002.2021.1857455
UR  - https://pub.dzne.de/record/155682
ER  -