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@ARTICLE{Ung:155682,
      author       = {Ung, Marie-Claire and Garrett, Lillian and Dalke, Claudia
                      and Leitner, Valentin and Dragosa, Daniel and Hladik,
                      Daniela and Neff, Frauke and Wagner, Florian and
                      Zitzelsberger, Horst and Miller, Gregor and de Angelis,
                      Martin Hrabě and Rößler, Ute and Vogt Weisenhorn, Daniela
                      and Wurst, Wolfgang and Graw, Jochen and Hölter, Sabine M},
      title        = {{D}ose-dependent long-term effects of a single radiation
                      event on behaviour and glial cells.},
      journal      = {International journal of radiation biology},
      volume       = {97},
      number       = {2},
      issn         = {1362-3095},
      address      = {Abingdon},
      publisher    = {Informa Healthcare},
      reportid     = {DZNE-2021-00850},
      pages        = {156 - 169},
      year         = {2021},
      note         = {ISSN 1362-3095 not unique: **2 hits**.},
      abstract     = {The increasing use of low-dose ionizing radiation in
                      medicine requires a systematic study of its long-term
                      effects on the brain, behaviour and its possible association
                      with neurodegenerative disease vulnerability. Therefore, we
                      analysed the long-term effects of a single low-dose
                      irradiation exposure at 10 weeks of age compared to medium
                      and higher doses on locomotor, emotion-related and
                      sensorimotor behaviour in mice as well as on hippocampal
                      glial cell populations.We determined the influence of
                      radiation dose (0, 0.063, 0.125 or 0.5 Gy), time
                      post-irradiation (4, 12 and 18 months p.i.), sex and
                      genotype (wild type versus mice with Ercc2 DNA repair gene
                      point mutation) on behaviour.The high dose (0.5 Gy) had
                      early-onset adverse effects at 4 months p.i. on sensorimotor
                      recruitment and late-onset negative locomotor effects at 12
                      and 18 months p.i. Notably, the low dose (0.063 Gy) produced
                      no early effects but subtle late-onset (18 months)
                      protective effects on sensorimotor recruitment and
                      exploratory behaviour. Quantification and morphological
                      characterization of the microglial and the astrocytic cells
                      of the dentate gyrus 24 months p.i. indicated heightened
                      immune activity after high dose irradiation (0.125 and 0.5
                      Gy) while conversely, low dose (0.063 Gy) induced more
                      neuroprotective features.This is one of the first studies
                      demonstrating such long-term and late-onset effects on brain
                      and behaviour after a single radiation event in adulthood.},
      keywords     = {Animals / Behavior, Animal: radiation effects /
                      Dose-Response Relationship, Radiation / Female /
                      Hippocampus: radiation effects / Male / Mice / Mice, Inbred
                      C3H / Mice, Inbred C57BL / Motor Activity: radiation effects
                      / Neuroglia: radiation effects / Whole-Body Irradiation /
                      Xeroderma Pigmentosum Group D Protein: genetics /
                      Irradiation (Other) / astrocytes (Other) / behavior (Other)
                      / brain (Other) / mice (Other) / microglia (Other) /
                      Xeroderma Pigmentosum Group D Protein (NLM Chemicals) /
                      Ercc2 protein, mouse (NLM Chemicals)},
      cin          = {AG Wurst},
      ddc          = {570},
      cid          = {I:(DE-2719)1140001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33264576},
      doi          = {10.1080/09553002.2021.1857455},
      url          = {https://pub.dzne.de/record/155682},
}