000155685 001__ 155685
000155685 005__ 20240122130402.0
000155685 0247_ $$2doi$$a10.1016/j.parkreldis.2020.11.015
000155685 0247_ $$2pmid$$apmid:33242663
000155685 0247_ $$2ISSN$$a1353-8020
000155685 0247_ $$2ISSN$$a1873-5126
000155685 0247_ $$2altmetric$$aaltmetric:95011292
000155685 037__ $$aDZNE-2021-00853
000155685 041__ $$aEnglish
000155685 082__ $$a610
000155685 1001_ $$0P:(DE-2719)2811919$$aSulzer, Patricia$$b0$$eFirst author$$udzne
000155685 245__ $$aCognitive impairment and sedentary behavior predict health-related attrition in a prospective longitudinal Parkinson's disease study.
000155685 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
000155685 3367_ $$2DRIVER$$aarticle
000155685 3367_ $$2DataCite$$aOutput Types/Journal article
000155685 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1705924996_13658
000155685 3367_ $$2BibTeX$$aARTICLE
000155685 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000155685 3367_ $$00$$2EndNote$$aJournal Article
000155685 520__ $$aIn Parkinson's disease (PD), the high burden of motor and non-motor symptoms, such as cognitive impairment or falls, is associated with rapid disease progression and mortality. This is often reflected by an increased drop-out rate of PD patients in longitudinal studies. Active physical behavior can impact the disease course beneficially and has an overall positive effect on health. Contrarily, sedentary behavior is associated with cognitive impairment in PD. The aim of this study was to investigate whether sedentary physical behavior assessed in the home environment and cognitive impairment can predict health-related study attrition due to sickness and death in PD.Data of 45 PD patients, longitudinally assessed, were analyzed. Of those, 20 patients completed six yearly visits, 16 dropped out due to sickness or death, and nine for other reasons. All patients wore a mobile device to assess physical behavior and completed cognitive testing.Logistic regression revealed global cognition was the primary predictor for health-related drop-out in varying models (p ≤ .04). In the survival analysis, cognitive impairment (p = .005) and longer sedentary mean bout length (p = .02) were associated with drop-out due to sickness and death. The occurrence of health-related study drop-out or death was highest in patients with both impaired cognition and longer sedentary bouts.Cognition was the primary predictor for study drop-out due to sickness and death. However, it seems that sedentary behavior might have a potential negative influence on PD patients' health, especially those with cognitive impairment.
000155685 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000155685 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000155685 650_7 $$2Other$$aAccelerometer
000155685 650_7 $$2Other$$aAttrition
000155685 650_7 $$2Other$$aCognition
000155685 650_7 $$2Other$$aDisease progression
000155685 650_7 $$2Other$$aParkinson's disease
000155685 650_7 $$2Other$$aPhysical behavior
000155685 650_7 $$2Other$$aSedentary behavior
000155685 650_2 $$2MeSH$$aAdult
000155685 650_2 $$2MeSH$$aAged
000155685 650_2 $$2MeSH$$aAged, 80 and over
000155685 650_2 $$2MeSH$$aCognitive Dysfunction: etiology
000155685 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000155685 650_2 $$2MeSH$$aDisease Progression
000155685 650_2 $$2MeSH$$aFemale
000155685 650_2 $$2MeSH$$aHumans
000155685 650_2 $$2MeSH$$aLongitudinal Studies
000155685 650_2 $$2MeSH$$aMale
000155685 650_2 $$2MeSH$$aMiddle Aged
000155685 650_2 $$2MeSH$$aParkinson Disease: complications
000155685 650_2 $$2MeSH$$aParkinson Disease: mortality
000155685 650_2 $$2MeSH$$aParkinson Disease: physiopathology
000155685 650_2 $$2MeSH$$aPatient Dropouts
000155685 650_2 $$2MeSH$$aPrognosis
000155685 650_2 $$2MeSH$$aSedentary Behavior
000155685 7001_ $$0P:(DE-2719)2810662$$aGräber-Sultan, Susanne$$b1$$udzne
000155685 7001_ $$0P:(DE-2719)2811829$$aSchäffer, Eva$$b2$$udzne
000155685 7001_ $$avan Lummel, Rob$$b3
000155685 7001_ $$0P:(DE-2719)2000059$$aBerg, Daniela$$b4$$udzne
000155685 7001_ $$0P:(DE-2719)2810915$$aMaetzler, Walter$$b5$$udzne
000155685 7001_ $$0P:(DE-2719)2109499$$aLiepelt-Scarfone, Inga$$b6$$eLast author$$udzne
000155685 773__ $$0PERI:(DE-600)2027635-7$$a10.1016/j.parkreldis.2020.11.015$$gVol. 82, p. 37 - 43$$p37 - 43$$tParkinsonism & related disorders$$v82$$x1353-8020$$y2021
000155685 8564_ $$uhttps://pub.dzne.de/record/155685/files/DZNE-2021-00853_Restricted.pdf
000155685 8564_ $$uhttps://pub.dzne.de/record/155685/files/DZNE-2021-00853_Restricted.pdf?subformat=pdfa$$xpdfa
000155685 909CO $$ooai:pub.dzne.de:155685$$pVDB
000155685 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811919$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000155685 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810662$$aExternal Institute$$b1$$kExtern
000155685 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811829$$aExternal Institute$$b2$$kExtern
000155685 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2000059$$aExternal Institute$$b4$$kExtern
000155685 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810915$$aExternal Institute$$b5$$kExtern
000155685 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2109499$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000155685 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000155685 9130_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0
000155685 9130_ $$0G:(DE-HGF)POF3-345$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vPopulation Studies and Genetics$$x1
000155685 9141_ $$y2021
000155685 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000155685 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000155685 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPARKINSONISM RELAT D : 2021$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-12
000155685 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2022-11-12
000155685 9201_ $$0I:(DE-2719)1210000$$kAG Gasser$$lParkinson Genetics$$x0
000155685 9201_ $$0I:(DE-2719)1240005$$kCore ICRU$$lCore ICRU$$x1
000155685 980__ $$ajournal
000155685 980__ $$aVDB
000155685 980__ $$aI:(DE-2719)1210000
000155685 980__ $$aI:(DE-2719)1240005
000155685 980__ $$aUNRESTRICTED