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@ARTICLE{Sulzer:155685,
      author       = {Sulzer, Patricia and Gräber-Sultan, Susanne and Schäffer,
                      Eva and van Lummel, Rob and Berg, Daniela and Maetzler,
                      Walter and Liepelt-Scarfone, Inga},
      title        = {{C}ognitive impairment and sedentary behavior predict
                      health-related attrition in a prospective longitudinal
                      {P}arkinson's disease study.},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {82},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2021-00853},
      pages        = {37 - 43},
      year         = {2021},
      abstract     = {In Parkinson's disease (PD), the high burden of motor and
                      non-motor symptoms, such as cognitive impairment or falls,
                      is associated with rapid disease progression and mortality.
                      This is often reflected by an increased drop-out rate of PD
                      patients in longitudinal studies. Active physical behavior
                      can impact the disease course beneficially and has an
                      overall positive effect on health. Contrarily, sedentary
                      behavior is associated with cognitive impairment in PD. The
                      aim of this study was to investigate whether sedentary
                      physical behavior assessed in the home environment and
                      cognitive impairment can predict health-related study
                      attrition due to sickness and death in PD.Data of 45 PD
                      patients, longitudinally assessed, were analyzed. Of those,
                      20 patients completed six yearly visits, 16 dropped out due
                      to sickness or death, and nine for other reasons. All
                      patients wore a mobile device to assess physical behavior
                      and completed cognitive testing.Logistic regression revealed
                      global cognition was the primary predictor for
                      health-related drop-out in varying models (p ≤ .04). In
                      the survival analysis, cognitive impairment (p = .005) and
                      longer sedentary mean bout length (p = .02) were
                      associated with drop-out due to sickness and death. The
                      occurrence of health-related study drop-out or death was
                      highest in patients with both impaired cognition and longer
                      sedentary bouts.Cognition was the primary predictor for
                      study drop-out due to sickness and death. However, it seems
                      that sedentary behavior might have a potential negative
                      influence on PD patients' health, especially those with
                      cognitive impairment.},
      keywords     = {Adult / Aged / Aged, 80 and over / Cognitive Dysfunction:
                      etiology / Cognitive Dysfunction: physiopathology / Disease
                      Progression / Female / Humans / Longitudinal Studies / Male
                      / Middle Aged / Parkinson Disease: complications / Parkinson
                      Disease: mortality / Parkinson Disease: physiopathology /
                      Patient Dropouts / Prognosis / Sedentary Behavior /
                      Accelerometer (Other) / Attrition (Other) / Cognition
                      (Other) / Disease progression (Other) / Parkinson's disease
                      (Other) / Physical behavior (Other) / Sedentary behavior
                      (Other)},
      cin          = {AG Gasser / Core ICRU},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)1240005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33242663},
      doi          = {10.1016/j.parkreldis.2020.11.015},
      url          = {https://pub.dzne.de/record/155685},
}