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000155688 037__ $$aDZNE-2021-00856
000155688 041__ $$aEnglish
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000155688 1001_ $$0P:(DE-2719)2810271$$aTavosanis, Gaia$$b0$$eFirst author$$udzne
000155688 245__ $$aDendrite enlightenment.
000155688 260__ $$aPhiladelphia, Pa.$$bCurrent Biology$$c2021
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000155688 520__ $$aNeuronal dendrites acquire complex morphologies during development. These are not just the product of cell-intrinsic developmental programs; rather they are defined in close interaction with the cellular environment. Thus, to understand the molecular cascades that yield appropriate morphologies, it is essential to investigate them in vivo, in the actual complex tissue environment encountered by the differentiating neuron in the developing animal. Particularly, genetic approaches have pointed to factors controlling dendrite differentiation in vivo. These suggest that localized and transient molecular cascades might underlie the formation and stabilization of dendrite branches with neuron type-specific characteristics. Here, I highlight the need for studies of neuronal dendrite differentiation in the animal, the challenges provided by such an approach, and the promising pathways that have recently opened.
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000155688 650_2 $$2MeSH$$aAnimals
000155688 650_2 $$2MeSH$$aDendrites
000155688 650_2 $$2MeSH$$aNeurons
000155688 773__ $$0PERI:(DE-600)2013035-1$$a10.1016/j.conb.2021.05.001$$gVol. 69, p. 222 - 230$$p222 - 230$$tCurrent opinion in neurobiology$$v69$$x0959-4388$$y2021
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000155688 9141_ $$y2021
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