TY  - JOUR
AU  - Tavosanis, Gaia
TI  - Dendrite enlightenment.
JO  - Current opinion in neurobiology
VL  - 69
SN  - 0959-4388
CY  - Philadelphia, Pa.
PB  - Current Biology
M1  - DZNE-2021-00856
SP  - 222 - 230
PY  - 2021
AB  - Neuronal dendrites acquire complex morphologies during development. These are not just the product of cell-intrinsic developmental programs; rather they are defined in close interaction with the cellular environment. Thus, to understand the molecular cascades that yield appropriate morphologies, it is essential to investigate them in vivo, in the actual complex tissue environment encountered by the differentiating neuron in the developing animal. Particularly, genetic approaches have pointed to factors controlling dendrite differentiation in vivo. These suggest that localized and transient molecular cascades might underlie the formation and stabilization of dendrite branches with neuron type-specific characteristics. Here, I highlight the need for studies of neuronal dendrite differentiation in the animal, the challenges provided by such an approach, and the promising pathways that have recently opened.
KW  - Animals
KW  - Dendrites
KW  - Neurons
LB  - PUB:(DE-HGF)16
C6  - pmid:34134010
DO  - DOI:10.1016/j.conb.2021.05.001
UR  - https://pub.dzne.de/record/155688
ER  -