000155695 001__ 155695
000155695 005__ 20240403115639.0
000155695 0247_ $$2doi$$a10.3390/cancers13143618
000155695 0247_ $$2pmid$$apmid:34298830
000155695 0247_ $$2pmc$$apmc:PMC8303406
000155695 037__ $$aDZNE-2021-00863
000155695 041__ $$aEnglish
000155695 082__ $$a610
000155695 1001_ $$aBusch, Julia$$b0
000155695 245__ $$aTRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks.
000155695 260__ $$aBasel$$bMDPI$$c2021
000155695 3367_ $$2DRIVER$$aarticle
000155695 3367_ $$2DataCite$$aOutput Types/Journal article
000155695 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1712136068_27005
000155695 3367_ $$2BibTeX$$aARTICLE
000155695 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000155695 3367_ $$00$$2EndNote$$aJournal Article
000155695 520__ $$aThe ubiquitin E3 ligase TNF Receptor Associated Factor 6 (TRAF6) participates in a large number of different biological processes including innate immunity, differentiation and cell survival, raising the need to specify and shape the signaling output. Here, we identify a lipopolysaccharide (LPS)-dependent increase in TRAF6 association with the kinase IKKε (inhibitor of NF-κB kinase subunit ε) and IKKε-mediated TRAF6 phosphorylation at five residues. The reconstitution of TRAF6-deficient cells, with TRAF6 mutants representing phosphorylation-defective or phospho-mimetic TRAF6 variants, showed that the phospho-mimetic TRAF6 variant was largely protected from basal ubiquitin/proteasome-mediated degradation, and also from autophagy-mediated decay in autolysosomes induced by metabolic perturbation. In addition, phosphorylation of TRAF6 and its E3 ligase function differentially shape basal and LPS-triggered signaling networks, as revealed by phosphoproteome analysis. Changes in LPS-triggered phosphorylation networks of cells that had experienced autophagy are partially dependent on TRAF6 and its phosphorylation status, suggesting an involvement of this E3 ligase in the interplay between metabolic and inflammatory circuits.
000155695 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000155695 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000155695 650_7 $$2Other$$aIKKε
000155695 650_7 $$2Other$$aLPS
000155695 650_7 $$2Other$$aNF-κB
000155695 650_7 $$2Other$$aTRAF6
000155695 650_7 $$2Other$$aautophagy
000155695 650_7 $$2Other$$akinase activation
000155695 650_7 $$2Other$$aphosphorylation
000155695 650_7 $$2Other$$asignaling
000155695 7001_ $$aMoreno, Rita$$b1
000155695 7001_ $$0P:(DE-HGF)0$$ade la Vega, Laureano$$b2
000155695 7001_ $$aSaul, Vera Vivian$$b3
000155695 7001_ $$aBacher, Susanne$$b4
000155695 7001_ $$0P:(DE-2719)2811552$$aZweydorf, Felix$$b5$$udzne
000155695 7001_ $$0P:(DE-HGF)0$$aUeffing, Marius$$b6
000155695 7001_ $$0P:(DE-HGF)0$$aWeber, Axel$$b7
000155695 7001_ $$0P:(DE-2719)2811291$$aGloeckner, Christian Johannes$$b8$$udzne
000155695 7001_ $$0P:(DE-HGF)0$$aLinne, Uwe$$b9
000155695 7001_ $$0P:(DE-HGF)0$$aKracht, Michael$$b10
000155695 7001_ $$0P:(DE-HGF)0$$aSchmitz, Michael Lienhard$$b11
000155695 770__ $$aNF-kB Signaling in Cellular Responses to Threats, Cancer Development and Therapy
000155695 773__ $$0PERI:(DE-600)2527080-1$$a10.3390/cancers13143618$$gVol. 13, no. 14, p. 3618 -$$n14$$p3618$$tCancers$$v13$$x2072-6694$$y2021
000155695 8564_ $$uhttps://pub.dzne.de/record/155695/files/DZNE-2021-00863.pdf$$yOpenAccess
000155695 8564_ $$uhttps://pub.dzne.de/record/155695/files/DZNE-2021-00863.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000155695 909CO $$ooai:pub.dzne.de:155695$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000155695 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811552$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000155695 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811291$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000155695 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000155695 9130_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000155695 9141_ $$y2021
000155695 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-30
000155695 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-05-04
000155695 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-05-04
000155695 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCANCERS : 2021$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-01-24T07:56:58Z
000155695 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-05-04
000155695 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-01-24T07:56:58Z
000155695 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000155695 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-05-04
000155695 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCANCERS : 2021$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-05-04
000155695 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-30
000155695 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-05-04
000155695 9201_ $$0I:(DE-2719)1210007$$kAG Gloeckner$$lFunctional Neuroproteomics and Translational Biomarkers in Neurodegenerative Diseases$$x0
000155695 980__ $$ajournal
000155695 980__ $$aVDB
000155695 980__ $$aUNRESTRICTED
000155695 980__ $$aI:(DE-2719)1210007
000155695 9801_ $$aFullTexts