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001     155703
005     20240119110757.0
024 7 _ |a 10.1016/j.molmed.2020.09.001
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024 7 _ |a pmid:33008729
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024 7 _ |a 1471-4914
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037 _ _ |a DZNE-2021-00871
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Provenzano, Francesca
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245 _ _ |a Redefining Microglial Identity in Health and Disease at Single-Cell Resolution.
260 _ _ |a Amsterdam [u.a.]
|c 2021
|b Elsevier Science
336 7 _ |a article
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520 _ _ |a Microglia have long been considered a homogenous cell population that uniformly responds to extrinsic factors. Here, we describe how the recent development of single-cell technologies has revealed the heterogeneity of both human and mouse microglia and identified distinct microglial states linked to specific developmental, aging, and disease stages. We discuss progress and future developments in data analysis, essential tools for the comprehension of big data derived from single-cell omics, and the necessity of integrating such data with functional studies to correlate genetic cues with the relevant biological functions of microglia. Defining the functional correlates of distinct microglia states is fundamental to dissecting the 'microglial etiology' of aging and complex neurological diseases and identifying novel therapeutic and diagnostic targets.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Disease Susceptibility
|2 MeSH
650 _ 2 |a Genomics: methods
|2 MeSH
650 _ 2 |a Homeostasis
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Metabolomics: methods
|2 MeSH
650 _ 2 |a Microglia: physiology
|2 MeSH
650 _ 2 |a Proteomics: methods
|2 MeSH
650 _ 2 |a Single-Cell Analysis: methods
|2 MeSH
700 1 _ |a Pérez, María José
|0 P:(DE-2719)9001465
|b 1
|u dzne
700 1 _ |a Deleidi, Michela
|0 P:(DE-2719)2810385
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|e Last author
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773 _ _ |a 10.1016/j.molmed.2020.09.001
|g Vol. 27, no. 1, p. 47 - 59
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|p 47 - 59
|t Trends in molecular medicine
|v 27
|y 2021
|x 1471-4914
856 4 _ |u https://pub.dzne.de/record/155703/files/DZNE-2021-00871_Restricted.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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