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@ARTICLE{Bergstrm:155714,
      author       = {Bergström, Sofia and Remnestål, Julia and Yousef, Jamil
                      and Olofsson, Jennie and Markaki, Ioanna and Carvalho,
                      Stephanie and Corvol, Jean-Christophe and Kultima, Kim and
                      Kilander, Lena and Löwenmark, Malin and Ingelsson, Martin
                      and Blennow, Kaj and Zetterberg, Henrik and Nellgård, Bengt
                      and Brosseron, Frederic and Heneka, Michael and Bosch,
                      Beatriz and Sanchez-Valle, Raquel and Månberg, Anna and
                      Svenningsson, Per and Nilsson, Peter},
      title        = {{M}ulti-cohort profiling reveals elevated {CSF} levels of
                      brain-enriched proteins in {A}lzheimer's disease.},
      journal      = {Annals of Clinical and Translational Neurology},
      volume       = {8},
      number       = {7},
      issn         = {2328-9503},
      address      = {Chichester [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00882},
      pages        = {1456 - 1470},
      year         = {2021},
      abstract     = {Decreased amyloid beta (Aβ) 42 together with increased tau
                      and phospho-tau in cerebrospinal fluid (CSF) is indicative
                      of Alzheimer's disease (AD). However, the molecular
                      pathophysiology underlying the slowly progressive cognitive
                      decline observed in AD is not fully understood and it is not
                      known what other CSF biomarkers may be altered in early
                      disease stages.We utilized an antibody-based suspension bead
                      array to analyze levels of 216 proteins in CSF from AD
                      patients, patients with mild cognitive impairment (MCI), and
                      controls from two independent cohorts collected within the
                      AETIONOMY consortium. Two additional cohorts from Sweden
                      were used for biological verification.Six proteins,
                      amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated
                      phosphoprotein 21 (ARPP21), growth-associated protein 43
                      (GAP43), neurofilament medium polypeptide (NEFM), and
                      synuclein beta (SNCB) were found at increased levels in CSF
                      from AD patients compared with controls. Next, we used CSF
                      levels of Aβ42 and tau for the stratification of the MCI
                      patients and observed increased levels of AMPH, AQP4,
                      ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal
                      tau levels compared with controls. Further characterization
                      revealed strong to moderate correlations between these five
                      proteins and tau concentrations.In conclusion, we report six
                      extensively replicated candidate biomarkers with the
                      potential to reflect disease development. Continued
                      evaluation of these proteins will determine to what extent
                      they can aid in the discrimination of MCI patients with and
                      without an underlying AD etiology, and if they have the
                      potential to contribute to a better understanding of the AD
                      continuum.},
      keywords     = {Adult / Aged / Aged, 80 and over / Alzheimer Disease:
                      cerebrospinal fluid / Alzheimer Disease: diagnosis / Amyloid
                      beta-Peptides: cerebrospinal fluid / Aquaporin 4:
                      cerebrospinal fluid / Biomarkers: cerebrospinal fluid /
                      Brain: metabolism / Cognitive Dysfunction: cerebrospinal
                      fluid / Cognitive Dysfunction: diagnosis / Cohort Studies /
                      Cross-Sectional Studies / Female / GAP-43 Protein:
                      cerebrospinal fluid / Humans / Male / Middle Aged / Nerve
                      Tissue Proteins: cerebrospinal fluid / Neurofilament
                      Proteins: cerebrospinal fluid / Peptide Fragments:
                      cerebrospinal fluid / Phosphoproteins: cerebrospinal fluid /
                      Protein Array Analysis: methods / beta-Synuclein:
                      cerebrospinal fluid / tau Proteins: cerebrospinal fluid},
      cin          = {Biomarker},
      ddc          = {610},
      cid          = {I:(DE-2719)1011301},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34129723},
      pmc          = {pmc:PMC8283172},
      doi          = {10.1002/acn3.51402},
      url          = {https://pub.dzne.de/record/155714},
}