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@ARTICLE{vanderEnde:155720,
      author       = {van der Ende, Emma L and Morenas-Rodriguez, Estrella and
                      McMillan, Corey and Grossman, Murray and Irwin, David and
                      Sanchez-Valle, Raquel and Graff, Caroline and Vandenberghe,
                      Rik and Pijnenburg, Yolande A L and Laforce, Robert and Ber,
                      Isabelle Le and Lleo, Alberto and Haass, Christian and
                      Suarez-Calvet, Marc and van Swieten, John C and Seelaar,
                      Harro},
      title        = {{CSF} s{TREM}2 is elevated in a subset in {GRN}-related
                      frontotemporal dementia.},
      journal      = {Neurobiology of aging},
      volume       = {103},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2021-00888},
      pages        = {158.e1 - 158.e5},
      year         = {2021},
      abstract     = {Excessive microglial activation might be a central
                      pathological process in GRN-related frontotemporal dementia
                      (FTD-GRN). We measured soluble triggering receptor expressed
                      on myeloid cells 2 (sTREM2), which is shed from
                      disease-associated microglia following cleavage of TREM2, in
                      cerebrospinal fluid of 34 presymptomatic and 35 symptomatic
                      GRN mutation carriers, 6 presymptomatic and 32 symptomatic
                      C9orf72 mutation carriers and 67 healthy noncarriers by
                      ELISA. Although no group differences in sTREM2 levels were
                      observed (GRN: symptomatic (median 5.2 ng/mL, interquartile
                      range [3.9-9.2]) vs. presymptomatic (4.3 ng/mL [2.6-6.1])
                      vs. noncarriers (4.2 ng/mL [2.6-5.5]): p = 0.059; C9orf72:
                      symptomatic (4.3 [2.9-7.0]) vs. presymptomatic (3.2
                      [2.2-4.2]) vs. noncarriers: p = 0.294), high levels were
                      seen in a subset of GRN, but not C9orf72, mutation carriers,
                      which might reflect differential TREM2-related microglial
                      activation. Interestingly, 2 presymptomatic carriers with
                      low sTREM2 levels developed symptoms after 1 year, whereas 2
                      with high levels became symptomatic after >5 years. While
                      sTREM2 is not a promising diagnostic biomarker for FTD-GRN
                      or FTD-C9orf72, further research might elucidate its
                      potential to monitor microglial activity and predict disease
                      progression.},
      keywords     = {Adult / Aged / Biomarkers: cerebrospinal fluid / C9orf72
                      Protein: genetics / Female / Frontotemporal Dementia:
                      diagnosis / Frontotemporal Dementia: genetics / Heterozygote
                      / Humans / Male / Membrane Glycoproteins: cerebrospinal
                      fluid / Membrane Glycoproteins: metabolism / Microglia:
                      metabolism / Microglia: physiology / Middle Aged / Mutation
                      / Progranulins: genetics / Receptors, Immunologic:
                      metabolism / Biomarker (Other) / Cerebrospinal fluid (Other)
                      / Frontotemporal dementia (Other) / Microglia (Other) /
                      sTREM2 (Other)},
      cin          = {AG Haass},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33896652},
      doi          = {10.1016/j.neurobiolaging.2021.02.024},
      url          = {https://pub.dzne.de/record/155720},
}