Home > Publications Database > CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia. > print

001     155720
005     20240302115203.0
024 7 _ |a 10.1016/j.neurobiolaging.2021.02.024
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024 7 _ |a pmid:33896652
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024 7 _ |a 0197-4580
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024 7 _ |a 1558-1497
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037 _ _ |a DZNE-2021-00888
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a van der Ende, Emma L
|b 0
245 _ _ |a CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia.
260 _ _ |a Amsterdam [u.a.]
|c 2021
|b Elsevier Science
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. Although no group differences in sTREM2 levels were observed (GRN: symptomatic (median 5.2 ng/mL, interquartile range [3.9-9.2]) vs. presymptomatic (4.3 ng/mL [2.6-6.1]) vs. noncarriers (4.2 ng/mL [2.6-5.5]): p = 0.059; C9orf72: symptomatic (4.3 [2.9-7.0]) vs. presymptomatic (3.2 [2.2-4.2]) vs. noncarriers: p = 0.294), high levels were seen in a subset of GRN, but not C9orf72, mutation carriers, which might reflect differential TREM2-related microglial activation. Interestingly, 2 presymptomatic carriers with low sTREM2 levels developed symptoms after 1 year, whereas 2 with high levels became symptomatic after >5 years. While sTREM2 is not a promising diagnostic biomarker for FTD-GRN or FTD-C9orf72, further research might elucidate its potential to monitor microglial activity and predict disease progression.
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
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650 _ 7 |a Biomarker
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650 _ 7 |a Cerebrospinal fluid
|2 Other
650 _ 7 |a Frontotemporal dementia
|2 Other
650 _ 7 |a Microglia
|2 Other
650 _ 7 |a sTREM2
|2 Other
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Biomarkers: cerebrospinal fluid
|2 MeSH
650 _ 2 |a C9orf72 Protein: genetics
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: diagnosis
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: genetics
|2 MeSH
650 _ 2 |a Heterozygote
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Membrane Glycoproteins: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Membrane Glycoproteins: metabolism
|2 MeSH
650 _ 2 |a Microglia: metabolism
|2 MeSH
650 _ 2 |a Microglia: physiology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Mutation
|2 MeSH
650 _ 2 |a Progranulins: genetics
|2 MeSH
650 _ 2 |a Receptors, Immunologic: metabolism
|2 MeSH
700 1 _ |a Morenas-Rodriguez, Estrella
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700 1 _ |a McMillan, Corey
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700 1 _ |a Grossman, Murray
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700 1 _ |a Irwin, David
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700 1 _ |a Sanchez-Valle, Raquel
|b 5
700 1 _ |a Graff, Caroline
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700 1 _ |a Vandenberghe, Rik
|b 7
700 1 _ |a Pijnenburg, Yolande A L
|b 8
700 1 _ |a Laforce, Robert
|b 9
700 1 _ |a Ber, Isabelle Le
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700 1 _ |a Lleo, Alberto
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700 1 _ |a Haass, Christian
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700 1 _ |a Suarez-Calvet, Marc
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700 1 _ |a van Swieten, John C
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700 1 _ |a Seelaar, Harro
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773 _ _ |a 10.1016/j.neurobiolaging.2021.02.024
|g Vol. 103, p. 158.e1 - 158.e5
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|t Neurobiology of aging
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