TY  - JOUR
AU  - Babiloni, Claudio
AU  - Arakaki, Xianghong
AU  - Bonanni, Laura
AU  - Bujan, Ana
AU  - Carrillo, Maria C
AU  - Del Percio, Claudio
AU  - Edelmayer, Rebecca M
AU  - Egan, Gary
AU  - Elahh, Fanny M
AU  - Evans, Alan
AU  - Ferri, Raffaele
AU  - Frisoni, Giovanni B
AU  - Güntekin, Bahar
AU  - Hainsworth, Atticus
AU  - Hampel, Harald
AU  - Jelic, Vesna
AU  - Jeong, Jaeseung
AU  - Kim, Doh Kwan
AU  - Kramberger, Milica
AU  - Kumar, Sanjeev
AU  - Lizio, Roberta
AU  - Nobili, Flavio
AU  - Noce, Giuseppe
AU  - Puce, Aina
AU  - Ritter, Petra
AU  - Smit, Dirk J A
AU  - Soricelli, Andrea
AU  - Teipel, Stefan
AU  - Tucci, Federico
AU  - Sachdev, Perminder
AU  - Valdes-Sosa, Mitchell
AU  - Valdes-Sosa, Pedro
AU  - Vergallo, Andrea
AU  - Yener, Görsev
TI  - EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel.
JO  - Neurobiology of aging
VL  - 103
SN  - 0197-4580
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2021-00900
SP  - 78 - 97
PY  - 2021
AB  - Vascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found as abnormal in VCI patients with dementia. As compared to cognitively unimpaired individuals, those VCI patients showed (1) smaller amplitude of resting state alpha (8-12 Hz) rhythms dominant in posterior regions; (2) widespread increases in amplitude of delta (< 4 Hz) and theta (4-8 Hz) rhythms; and (3) delayed N200/P300 peak latencies in averaged event-related potentials, especially during the detection of auditory rare target stimuli requiring participants' responses in 'oddball' paradigms. The expert panel formulated the following recommendations: (1) the above EEG measures are not specific for VCI and should not be used for its diagnosis; (2) they may be considered as 'neural synchronization' biomarkers to enlighten the relationships between features of the VCI-related cerebrovascular lesions and abnormalities in neurophysiological brain mechanisms; and (3) they may be tested in future clinical trials as prognostic biomarkers and endpoints of interventions aimed at normalizing background brain excitability and vigilance in wakefulness.
KW  - Brain: physiopathology
KW  - Cognitive Dysfunction: diagnosis
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: physiopathology
KW  - Dementia, Vascular: diagnosis
KW  - Dementia, Vascular: etiology
KW  - Dementia, Vascular: physiopathology
KW  - Electroencephalography: methods
KW  - Evoked Potentials: physiology
KW  - Humans
KW  - Rest: physiology
KW  - Cerebrovascular disease (CVD) (Other)
KW  - Event-related oscillations (EROs) (Other)
KW  - Event-related potentials (ERPs) (Other)
KW  - Resting state electroencephalographic (rsEEG) rhythms (Other)
KW  - Small vessel disease (Other)
KW  - Subcortical ischemic vascular disease (Other)
KW  - Vascular cognitive impairment (VCI) (Other)
KW  - Vascular contribution to cognitive impairment and dementia (VCID) (Other)
KW  - Vascular dementia (VaD) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33845399
DO  - DOI:10.1016/j.neurobiolaging.2021.03.003
UR  - https://pub.dzne.de/record/155732
ER  -