%0 Journal Article
%A Ahn, Nayeon
%A Frenzel, Stefan
%A Wittfeld, Katharina
%A Bülow, Robin
%A Völzke, Henry
%A Lerch, Markus M
%A Chenot, Jean-Francois
%A Schminke, Ulf
%A Nolde, Michael
%A Amann, Ute
%A Meisinger, Christa
%A Linseisen, Jakob
%A Baumeister, Sebastian E
%A Grabe, Hans Jörgen
%A Rückert-Eheberg, Ina-Maria
%T Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study.
%J European journal of clinical pharmacology
%V 77
%N 7
%@ 1432-1041
%C New York
%I Springer
%M DZNE-2021-00920
%P 1039 - 1048
%D 2021
%X Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the general population.Two surveys of the population-based Study of Health in Pomerania (SHIP) conducted in Northeast Germany were used. In total, 2653 participants underwent brain magnetic resonance imaging (MRI) and were included in the primary analysis. They were divided into two groups according to their PPI intake and compared with regard to their brain volumes (gray matter, white matter, total brain, and hippocampus) and estimated brain age. Multiple regression was used to adjust for confounding factors. Cognitive function was evaluated by the Verbal Learning and Memory Test (VLMT) and the Nuremberg Age Inventory (NAI) and put in relation to PPI use.No association was found between PPI use and brain volumes or the estimated brain age. The VLMT score was 1.11 lower (95
%K Adult
%K Aged
%K Aged, 80 and over
%K Aging: drug effects
%K Brain: drug effects
%K Cognition: drug effects
%K Cross-Sectional Studies
%K Female
%K Germany
%K Humans
%K Male
%K Middle Aged
%K Proton Pump Inhibitors: administration & dosage
%K Proton Pump Inhibitors: adverse effects
%K Young Adult
%K Brain volume (Other)
%K Cognitive impairment (Other)
%K Dementia (Other)
%K Magnetic resonance imaging (Other)
%K Proton pump inhibitors (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33442768
%2 pmc:PMC8184524
%R 10.1007/s00228-020-03068-8
%U https://pub.dzne.de/record/155752