TY  - JOUR
AU  - Ahn, Nayeon
AU  - Frenzel, Stefan
AU  - Wittfeld, Katharina
AU  - Bülow, Robin
AU  - Völzke, Henry
AU  - Lerch, Markus M
AU  - Chenot, Jean-Francois
AU  - Schminke, Ulf
AU  - Nolde, Michael
AU  - Amann, Ute
AU  - Meisinger, Christa
AU  - Linseisen, Jakob
AU  - Baumeister, Sebastian E
AU  - Grabe, Hans Jörgen
AU  - Rückert-Eheberg, Ina-Maria
TI  - Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study.
JO  - European journal of clinical pharmacology
VL  - 77
IS  - 7
SN  - 1432-1041
CY  - New York
PB  - Springer
M1  - DZNE-2021-00920
SP  - 1039 - 1048
PY  - 2021
AB  - Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the general population.Two surveys of the population-based Study of Health in Pomerania (SHIP) conducted in Northeast Germany were used. In total, 2653 participants underwent brain magnetic resonance imaging (MRI) and were included in the primary analysis. They were divided into two groups according to their PPI intake and compared with regard to their brain volumes (gray matter, white matter, total brain, and hippocampus) and estimated brain age. Multiple regression was used to adjust for confounding factors. Cognitive function was evaluated by the Verbal Learning and Memory Test (VLMT) and the Nuremberg Age Inventory (NAI) and put in relation to PPI use.No association was found between PPI use and brain volumes or the estimated brain age. The VLMT score was 1.11 lower (95
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Aging: drug effects
KW  - Brain: drug effects
KW  - Cognition: drug effects
KW  - Cross-Sectional Studies
KW  - Female
KW  - Germany
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Proton Pump Inhibitors: administration & dosage
KW  - Proton Pump Inhibitors: adverse effects
KW  - Young Adult
KW  - Brain volume (Other)
KW  - Cognitive impairment (Other)
KW  - Dementia (Other)
KW  - Magnetic resonance imaging (Other)
KW  - Proton pump inhibitors (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33442768
C2  - pmc:PMC8184524
DO  - DOI:10.1007/s00228-020-03068-8
UR  - https://pub.dzne.de/record/155752
ER  -