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@ARTICLE{Ahn:155752,
      author       = {Ahn, Nayeon and Frenzel, Stefan and Wittfeld, Katharina and
                      Bülow, Robin and Völzke, Henry and Lerch, Markus M and
                      Chenot, Jean-Francois and Schminke, Ulf and Nolde, Michael
                      and Amann, Ute and Meisinger, Christa and Linseisen, Jakob
                      and Baumeister, Sebastian E and Grabe, Hans Jörgen and
                      Rückert-Eheberg, Ina-Maria},
      title        = {{L}ack of association between proton pump inhibitor use and
                      brain aging: a cross-sectional study.},
      journal      = {European journal of clinical pharmacology},
      volume       = {77},
      number       = {7},
      issn         = {1432-1041},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {DZNE-2021-00920},
      pages        = {1039 - 1048},
      year         = {2021},
      abstract     = {Due to conflicting scientific evidence for an increased
                      risk of dementia by intake of proton pump inhibitors (PPIs),
                      this study investigates associations between PPI use and
                      brain volumes, estimated brain age, and cognitive function
                      in the general population.Two surveys of the
                      population-based Study of Health in Pomerania (SHIP)
                      conducted in Northeast Germany were used. In total, 2653
                      participants underwent brain magnetic resonance imaging
                      (MRI) and were included in the primary analysis. They were
                      divided into two groups according to their PPI intake and
                      compared with regard to their brain volumes (gray matter,
                      white matter, total brain, and hippocampus) and estimated
                      brain age. Multiple regression was used to adjust for
                      confounding factors. Cognitive function was evaluated by the
                      Verbal Learning and Memory Test (VLMT) and the Nuremberg Age
                      Inventory (NAI) and put in relation to PPI use.No
                      association was found between PPI use and brain volumes or
                      the estimated brain age. The VLMT score was 1.11 lower
                      $(95\%$ confidence interval: - 2.06 to - 0.16) in immediate
                      recall, and 0.72 lower $(95\%$ CI: - 1.22 to - 0.22) in
                      delayed recall in PPI users than in non-users. PPI use was
                      unrelated to the NAI score.The present study does not
                      support a relationship between PPI use and brain aging.},
      keywords     = {Adult / Aged / Aged, 80 and over / Aging: drug effects /
                      Brain: drug effects / Cognition: drug effects /
                      Cross-Sectional Studies / Female / Germany / Humans / Male /
                      Middle Aged / Proton Pump Inhibitors: administration $\&$
                      dosage / Proton Pump Inhibitors: adverse effects / Young
                      Adult / Brain volume (Other) / Cognitive impairment (Other)
                      / Dementia (Other) / Magnetic resonance imaging (Other) /
                      Proton pump inhibitors (Other)},
      cin          = {AG Grabe / AG Hoffmann},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001 / I:(DE-2719)1510600},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33442768},
      pmc          = {pmc:PMC8184524},
      doi          = {10.1007/s00228-020-03068-8},
      url          = {https://pub.dzne.de/record/155752},
}