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000155892 0247_ $$2doi$$a10.1007/s00702-021-02411-2
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000155892 0247_ $$2ISSN$$a0022-3026
000155892 037__ $$aDZNE-2021-01052
000155892 041__ $$aEnglish
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000155892 1001_ $$00000-0003-0319-7374$$aGómez de San José, Nerea$$b0$$eFirst author
000155892 245__ $$aNeuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration.
000155892 260__ $$aWien [u.a.]$$bSpringer$$c2022
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000155892 520__ $$aThe diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms are still poorly characterised. Reliable quantification of synaptic damage is crucial to understand the pathophysiology of neurodegeneration, to track disease status and to obtain prognostic information. Neuronal pentraxins (NPTXs) are extracellular scaffolding proteins emerging as potential biomarkers of synaptic dysfunction in neurodegeneration. They are a family of proteins involved in homeostatic synaptic plasticity by recruiting post-synaptic receptors into synapses. Recent research investigates the dynamic changes of NPTXs in the cerebrospinal fluid (CSF) as an expression of synaptic damage, possibly related to cognitive impairment. In this review, we summarise the available data on NPTXs structure and expression patterns as well as on their contribution in synaptic function and plasticity and other less well-characterised roles. Moreover, we propose a mechanism for their involvement in synaptic damage and neurodegeneration and assess their potential as CSF biomarkers for neurodegenerative diseases.
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000155892 650_7 $$2Other$$aBiomarker
000155892 650_7 $$2Other$$aCerebrospinal fluid
000155892 650_7 $$2Other$$aNeurodegeneration
000155892 650_7 $$2Other$$aNeuronal pentraxin
000155892 650_7 $$2Other$$aSynapse
000155892 650_7 $$2Other$$aSynaptic function
000155892 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000155892 650_2 $$2MeSH$$aC-Reactive Protein
000155892 650_2 $$2MeSH$$aNerve Tissue Proteins: metabolism
000155892 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000155892 650_2 $$2MeSH$$aSynapses: metabolism
000155892 7001_ $$00000-0001-5667-204X$$aMassa, Federico$$b1
000155892 7001_ $$00000-0002-8711-5702$$aHalbgebauer, Steffen$$b2
000155892 7001_ $$0P:(DE-2719)9001560$$aOeckl, Patrick$$b3$$udzne
000155892 7001_ $$00000-0001-6697-6522$$aSteinacker, Petra$$b4
000155892 7001_ $$00000-0003-4273-4267$$aOtto, Markus$$b5$$eCorresponding author
000155892 773__ $$0PERI:(DE-600)1481655-6$$a10.1007/s00702-021-02411-2$$n2$$p207-230$$tJournal of neural transmission$$v129$$x1435-1463$$y2022
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