TY  - JOUR
AU  - Gómez de San José, Nerea
AU  - Massa, Federico
AU  - Halbgebauer, Steffen
AU  - Oeckl, Patrick
AU  - Steinacker, Petra
AU  - Otto, Markus
TI  - Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration.
JO  - Journal of neural transmission
VL  - 129
IS  - 2
SN  - 1435-1463
CY  - Wien [u.a.]
PB  - Springer
M1  - DZNE-2021-01052
SP  - 207-230
PY  - 2022
AB  - The diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms are still poorly characterised. Reliable quantification of synaptic damage is crucial to understand the pathophysiology of neurodegeneration, to track disease status and to obtain prognostic information. Neuronal pentraxins (NPTXs) are extracellular scaffolding proteins emerging as potential biomarkers of synaptic dysfunction in neurodegeneration. They are a family of proteins involved in homeostatic synaptic plasticity by recruiting post-synaptic receptors into synapses. Recent research investigates the dynamic changes of NPTXs in the cerebrospinal fluid (CSF) as an expression of synaptic damage, possibly related to cognitive impairment. In this review, we summarise the available data on NPTXs structure and expression patterns as well as on their contribution in synaptic function and plasticity and other less well-characterised roles. Moreover, we propose a mechanism for their involvement in synaptic damage and neurodegeneration and assess their potential as CSF biomarkers for neurodegenerative diseases.
KW  - Biomarkers: cerebrospinal fluid
KW  - C-Reactive Protein
KW  - Nerve Tissue Proteins: metabolism
KW  - Neuronal Plasticity: physiology
KW  - Synapses: metabolism
KW  - Biomarker (Other)
KW  - Cerebrospinal fluid (Other)
KW  - Neurodegeneration (Other)
KW  - Neuronal pentraxin (Other)
KW  - Synapse (Other)
KW  - Synaptic function (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8866268
C6  - pmid:34460014
DO  - DOI:10.1007/s00702-021-02411-2
UR  - https://pub.dzne.de/record/155892
ER  -