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@ARTICLE{GmezdeSanJos:155892,
      author       = {Gómez de San José, Nerea and Massa, Federico and
                      Halbgebauer, Steffen and Oeckl, Patrick and Steinacker,
                      Petra and Otto, Markus},
      title        = {{N}euronal pentraxins as biomarkers of synaptic activity:
                      from physiological functions to pathological changes in
                      neurodegeneration.},
      journal      = {Journal of neural transmission},
      volume       = {129},
      number       = {2},
      issn         = {1435-1463},
      address      = {Wien [u.a.]},
      publisher    = {Springer},
      reportid     = {DZNE-2021-01052},
      pages        = {207-230},
      year         = {2022},
      abstract     = {The diagnosis of neurodegenerative disorders is often
                      challenging due to the lack of diagnostic tools,
                      comorbidities and shared pathological manifestations.
                      Synaptic dysfunction is an early pathological event in many
                      neurodegenerative disorders, but the underpinning mechanisms
                      are still poorly characterised. Reliable quantification of
                      synaptic damage is crucial to understand the pathophysiology
                      of neurodegeneration, to track disease status and to obtain
                      prognostic information. Neuronal pentraxins (NPTXs) are
                      extracellular scaffolding proteins emerging as potential
                      biomarkers of synaptic dysfunction in neurodegeneration.
                      They are a family of proteins involved in homeostatic
                      synaptic plasticity by recruiting post-synaptic receptors
                      into synapses. Recent research investigates the dynamic
                      changes of NPTXs in the cerebrospinal fluid (CSF) as an
                      expression of synaptic damage, possibly related to cognitive
                      impairment. In this review, we summarise the available data
                      on NPTXs structure and expression patterns as well as on
                      their contribution in synaptic function and plasticity and
                      other less well-characterised roles. Moreover, we propose a
                      mechanism for their involvement in synaptic damage and
                      neurodegeneration and assess their potential as CSF
                      biomarkers for neurodegenerative diseases.},
      subtyp        = {Review Article},
      keywords     = {Biomarkers: cerebrospinal fluid / C-Reactive Protein /
                      Nerve Tissue Proteins: metabolism / Neuronal Plasticity:
                      physiology / Synapses: metabolism / Biomarker (Other) /
                      Cerebrospinal fluid (Other) / Neurodegeneration (Other) /
                      Neuronal pentraxin (Other) / Synapse (Other) / Synaptic
                      function (Other)},
      cin          = {AG Öckl},
      ddc          = {610},
      cid          = {I:(DE-2719)5000073},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8866268},
      pubmed       = {pmid:34460014},
      doi          = {10.1007/s00702-021-02411-2},
      url          = {https://pub.dzne.de/record/155892},
}