Home > Publications Database > Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration. > print

001     155892
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024 7 _ |a pmc:PMC8866268
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024 7 _ |a 10.1007/s00702-021-02411-2
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024 7 _ |a pmid:34460014
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024 7 _ |a 1435-1463
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037 _ _ |a DZNE-2021-01052
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Gómez de San José, Nerea
|0 0000-0003-0319-7374
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245 _ _ |a Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration.
260 _ _ |a Wien [u.a.]
|c 2022
|b Springer
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520 _ _ |a The diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms are still poorly characterised. Reliable quantification of synaptic damage is crucial to understand the pathophysiology of neurodegeneration, to track disease status and to obtain prognostic information. Neuronal pentraxins (NPTXs) are extracellular scaffolding proteins emerging as potential biomarkers of synaptic dysfunction in neurodegeneration. They are a family of proteins involved in homeostatic synaptic plasticity by recruiting post-synaptic receptors into synapses. Recent research investigates the dynamic changes of NPTXs in the cerebrospinal fluid (CSF) as an expression of synaptic damage, possibly related to cognitive impairment. In this review, we summarise the available data on NPTXs structure and expression patterns as well as on their contribution in synaptic function and plasticity and other less well-characterised roles. Moreover, we propose a mechanism for their involvement in synaptic damage and neurodegeneration and assess their potential as CSF biomarkers for neurodegenerative diseases.
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650 _ 7 |a Biomarker
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650 _ 7 |a Cerebrospinal fluid
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650 _ 7 |a Neurodegeneration
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650 _ 7 |a Neuronal pentraxin
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650 _ 7 |a Synapse
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650 _ 7 |a Synaptic function
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650 _ 2 |a Biomarkers: cerebrospinal fluid
|2 MeSH
650 _ 2 |a C-Reactive Protein
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650 _ 2 |a Nerve Tissue Proteins: metabolism
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
650 _ 2 |a Synapses: metabolism
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700 1 _ |a Massa, Federico
|0 0000-0001-5667-204X
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700 1 _ |a Halbgebauer, Steffen
|0 0000-0002-8711-5702
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700 1 _ |a Oeckl, Patrick
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700 1 _ |a Steinacker, Petra
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700 1 _ |a Otto, Markus
|0 0000-0003-4273-4267
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|e Corresponding author
773 _ _ |a 10.1007/s00702-021-02411-2
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|p 207-230
|t Journal of neural transmission
|v 129
|y 2022
|x 1435-1463
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/155892/files/DZNE-2021-01052.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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