%0 Journal Article
%A Pofahl, Martin
%A Nikbakht, Negar
%A Haubrich, André
%A Nguyen, Theresa
%A Masala, Nicola
%A Distler, Fabian
%A Braganza, Oliver
%A Macke, Jakob H
%A Ewell, Laura A
%A Golcuk, Kurtulus
%A Beck, Heinz
%T Synchronous activity patterns in the dentate gyrus during immobility.
%J eLife
%V 10
%@ 2050-084X
%C Cambridge
%I eLife Sciences Publications
%M DZNE-2021-01132
%P e65786
%D 2021
%X The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also shows structured activity during immobility and sleep. The properties of these activity patterns at cellular resolution, and their role in hippocampal-dependent memory processes have remained unclear. Using dual-color in vivo two-photon Ca2+ imaging, we show that in immobile mice dentate granule cells generate sparse, synchronized activity patterns associated with entorhinal cortex activation. These population events are structured and modified by changes in the environment; and they incorporate place- and speed cells. Importantly, they are more similar than expected by chance to population patterns evoked during self-motion. Using optogenetic inhibition, we show that granule cell activity is not only required during exploration, but also during immobility in order to form dentate gyrus-dependent spatial memories.
%K Animals
%K Dentate Gyrus: physiology
%K Female
%K Immobilization
%K Male
%K Mice
%K Neuroimaging
%K Neurons: physiology
%K Optogenetics
%K dentate gyrus (Other)
%K hippocampus (Other)
%K learning & memory (Other)
%K mouse (Other)
%K neuroscience (Other)
%K pattern separation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33709911
%2 pmc:PMC7987346
%R 10.7554/eLife.65786
%U https://pub.dzne.de/record/156000