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000156000 1001_ $$0P:(DE-2719)9000253$$aPofahl, Martin$$b0$$udzne
000156000 245__ $$aSynchronous activity patterns in the dentate gyrus during immobility.
000156000 260__ $$aCambridge$$beLife Sciences Publications$$c2021
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000156000 520__ $$aThe hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also shows structured activity during immobility and sleep. The properties of these activity patterns at cellular resolution, and their role in hippocampal-dependent memory processes have remained unclear. Using dual-color in vivo two-photon Ca2+ imaging, we show that in immobile mice dentate granule cells generate sparse, synchronized activity patterns associated with entorhinal cortex activation. These population events are structured and modified by changes in the environment; and they incorporate place- and speed cells. Importantly, they are more similar than expected by chance to population patterns evoked during self-motion. Using optogenetic inhibition, we show that granule cell activity is not only required during exploration, but also during immobility in order to form dentate gyrus-dependent spatial memories.
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000156000 650_7 $$2Other$$adentate gyrus
000156000 650_7 $$2Other$$ahippocampus
000156000 650_7 $$2Other$$alearning & memory
000156000 650_7 $$2Other$$amouse
000156000 650_7 $$2Other$$aneuroscience
000156000 650_7 $$2Other$$apattern separation
000156000 650_2 $$2MeSH$$aAnimals
000156000 650_2 $$2MeSH$$aDentate Gyrus: physiology
000156000 650_2 $$2MeSH$$aFemale
000156000 650_2 $$2MeSH$$aImmobilization
000156000 650_2 $$2MeSH$$aMale
000156000 650_2 $$2MeSH$$aMice
000156000 650_2 $$2MeSH$$aNeuroimaging
000156000 650_2 $$2MeSH$$aNeurons: physiology
000156000 650_2 $$2MeSH$$aOptogenetics
000156000 7001_ $$aNikbakht, Negar$$b1
000156000 7001_ $$0P:(DE-2719)2812079$$aHaubrich, André$$b2$$udzne
000156000 7001_ $$aNguyen, Theresa$$b3
000156000 7001_ $$aMasala, Nicola$$b4
000156000 7001_ $$aDistler, Fabian$$b5
000156000 7001_ $$00000-0001-8508-1070$$aBraganza, Oliver$$b6
000156000 7001_ $$00000-0001-5154-8912$$aMacke, Jakob H$$b7
000156000 7001_ $$aEwell, Laura A$$b8
000156000 7001_ $$aGolcuk, Kurtulus$$b9
000156000 7001_ $$0P:(DE-2719)2000044$$aBeck, Heinz$$b10$$eLast author$$udzne
000156000 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.65786$$gVol. 10, p. e65786$$pe65786$$teLife$$v10$$x2050-084X$$y2021
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