TY  - JOUR
AU  - Pofahl, Martin
AU  - Nikbakht, Negar
AU  - Haubrich, André
AU  - Nguyen, Theresa
AU  - Masala, Nicola
AU  - Distler, Fabian
AU  - Braganza, Oliver
AU  - Macke, Jakob H
AU  - Ewell, Laura A
AU  - Golcuk, Kurtulus
AU  - Beck, Heinz
TI  - Synchronous activity patterns in the dentate gyrus during immobility.
JO  - eLife
VL  - 10
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - DZNE-2021-01132
SP  - e65786
PY  - 2021
AB  - The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also shows structured activity during immobility and sleep. The properties of these activity patterns at cellular resolution, and their role in hippocampal-dependent memory processes have remained unclear. Using dual-color in vivo two-photon Ca2+ imaging, we show that in immobile mice dentate granule cells generate sparse, synchronized activity patterns associated with entorhinal cortex activation. These population events are structured and modified by changes in the environment; and they incorporate place- and speed cells. Importantly, they are more similar than expected by chance to population patterns evoked during self-motion. Using optogenetic inhibition, we show that granule cell activity is not only required during exploration, but also during immobility in order to form dentate gyrus-dependent spatial memories.
KW  - Animals
KW  - Dentate Gyrus: physiology
KW  - Female
KW  - Immobilization
KW  - Male
KW  - Mice
KW  - Neuroimaging
KW  - Neurons: physiology
KW  - Optogenetics
KW  - dentate gyrus (Other)
KW  - hippocampus (Other)
KW  - learning & memory (Other)
KW  - mouse (Other)
KW  - neuroscience (Other)
KW  - pattern separation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33709911
C2  - pmc:PMC7987346
DO  - DOI:10.7554/eLife.65786
UR  - https://pub.dzne.de/record/156000
ER  -