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@ARTICLE{Pofahl:156000,
      author       = {Pofahl, Martin and Nikbakht, Negar and Haubrich, André and
                      Nguyen, Theresa and Masala, Nicola and Distler, Fabian and
                      Braganza, Oliver and Macke, Jakob H and Ewell, Laura A and
                      Golcuk, Kurtulus and Beck, Heinz},
      title        = {{S}ynchronous activity patterns in the dentate gyrus during
                      immobility.},
      journal      = {eLife},
      volume       = {10},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DZNE-2021-01132},
      pages        = {e65786},
      year         = {2021},
      abstract     = {The hippocampal dentate gyrus is an important relay
                      conveying sensory information from the entorhinal cortex to
                      the hippocampus proper. During exploration, the dentate
                      gyrus has been proposed to act as a pattern separator.
                      However, the dentate gyrus also shows structured activity
                      during immobility and sleep. The properties of these
                      activity patterns at cellular resolution, and their role in
                      hippocampal-dependent memory processes have remained
                      unclear. Using dual-color in vivo two-photon Ca2+ imaging,
                      we show that in immobile mice dentate granule cells generate
                      sparse, synchronized activity patterns associated with
                      entorhinal cortex activation. These population events are
                      structured and modified by changes in the environment; and
                      they incorporate place- and speed cells. Importantly, they
                      are more similar than expected by chance to population
                      patterns evoked during self-motion. Using optogenetic
                      inhibition, we show that granule cell activity is not only
                      required during exploration, but also during immobility in
                      order to form dentate gyrus-dependent spatial memories.},
      keywords     = {Animals / Dentate Gyrus: physiology / Female /
                      Immobilization / Male / Mice / Neuroimaging / Neurons:
                      physiology / Optogenetics / dentate gyrus (Other) /
                      hippocampus (Other) / learning $\&$ memory (Other) / mouse
                      (Other) / neuroscience (Other) / pattern separation (Other)},
      cin          = {Bonn common},
      ddc          = {600},
      cid          = {I:(DE-2719)6000011},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33709911},
      pmc          = {pmc:PMC7987346},
      doi          = {10.7554/eLife.65786},
      url          = {https://pub.dzne.de/record/156000},
}