Home > Publications Database > Synchronous activity patterns in the dentate gyrus during immobility. > print

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100 1 _ |a Pofahl, Martin
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245 _ _ |a Synchronous activity patterns in the dentate gyrus during immobility.
260 _ _ |a Cambridge
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520 _ _ |a The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. However, the dentate gyrus also shows structured activity during immobility and sleep. The properties of these activity patterns at cellular resolution, and their role in hippocampal-dependent memory processes have remained unclear. Using dual-color in vivo two-photon Ca2+ imaging, we show that in immobile mice dentate granule cells generate sparse, synchronized activity patterns associated with entorhinal cortex activation. These population events are structured and modified by changes in the environment; and they incorporate place- and speed cells. Importantly, they are more similar than expected by chance to population patterns evoked during self-motion. Using optogenetic inhibition, we show that granule cell activity is not only required during exploration, but also during immobility in order to form dentate gyrus-dependent spatial memories.
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650 _ 7 |a dentate gyrus
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650 _ 7 |a hippocampus
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650 _ 7 |a learning & memory
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650 _ 7 |a neuroscience
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650 _ 7 |a pattern separation
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650 _ 2 |a Animals
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650 _ 2 |a Dentate Gyrus: physiology
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650 _ 2 |a Female
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650 _ 2 |a Immobilization
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650 _ 2 |a Male
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650 _ 2 |a Mice
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650 _ 2 |a Neuroimaging
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650 _ 2 |a Neurons: physiology
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650 _ 2 |a Optogenetics
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700 1 _ |a Nikbakht, Negar
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700 1 _ |a Haubrich, André
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700 1 _ |a Nguyen, Theresa
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700 1 _ |a Masala, Nicola
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700 1 _ |a Distler, Fabian
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700 1 _ |a Braganza, Oliver
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700 1 _ |a Macke, Jakob H
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700 1 _ |a Ewell, Laura A
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700 1 _ |a Golcuk, Kurtulus
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700 1 _ |a Beck, Heinz
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773 _ _ |a 10.7554/eLife.65786
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