| 001 | 156003 | ||
| 005 | 20240328115555.0 | ||
| 024 | 7 | _ | |a 10.3390/pharmaceutics13030379 |2 doi |
| 024 | 7 | _ | |a pmid:33809385 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC7999378 |2 pmc |
| 024 | 7 | _ | |a altmetric:102431678 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-01135 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Scuteri, Damiana |0 0000-0001-5846-7058 |b 0 |
| 245 | _ | _ | |a Development and Translation of NanoBEO, a Nanotechnology-Based Delivery System of Bergamot Essential Oil Deprived of Furocumarins, in the Control of Agitation in Severe Dementia. |
| 260 | _ | _ | |a Basel |c 2021 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1711616219_27787 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Dementia is one of the most common causes of disability worldwide characterized by memory loss, cognitive impairment, and behavioral and psychological symptoms (BPSD), including agitation. Treatment of the latter consists of the off-label use of harmful atypical antipsychotics, though a significant reduction is afforded by pain control. The use of an essential oil endowed with analgesic properties and devoid of toxicity would represent an important option for the management of agitation in dementia. Therefore, the aim of this study was to engineer a nanotechnology delivery system based on solid lipid nanoparticles loaded with bergamot essential oil (BEO) and devised in the pharmaceutical form of an odorless cream (NanoBEO) to confirm its analgesic efficacy for further development and application to control agitation in dementia. BEO has proven strong antinociceptive and anti-allodynic properties and, in its bergapten-free form, it is completely devoid of phototoxicity. NanoBEO has been studied in vivo confirming the previously reported analgesic activity of BEO to which is now added its anti-itching properties. Due to the nanotechnology delivery system, the stability of titrated BEO components is guaranteed. Finally, the latter invention, currently under patent consideration, is smell-devoid allowing efficacy and safety to be established in double-blind clinical trials; until now the latter studies have been impeded in aromatherapy by the strong odor of essential oils. A clinical trial NCT04321889 has been designed to provide information about the efficacy and safety of NanoBEO on agitation and pain in patients suffering from severe dementia. |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a BPSD |2 Other |
| 650 | _ | 7 | |a agitation |2 Other |
| 650 | _ | 7 | |a dementia |2 Other |
| 650 | _ | 7 | |a essential oil of bergamot |2 Other |
| 650 | _ | 7 | |a nanotechnology delivery system |2 Other |
| 650 | _ | 7 | |a pain |2 Other |
| 700 | 1 | _ | |a Cassano, Roberta |0 0000-0001-6980-6799 |b 1 |
| 700 | 1 | _ | |a Trombino, Sonia |b 2 |
| 700 | 1 | _ | |a Russo, Rossella |0 0000-0001-8758-6523 |b 3 |
| 700 | 1 | _ | |a Mizoguchi, Hirokazu |b 4 |
| 700 | 1 | _ | |a Watanabe, Chizuko |b 5 |
| 700 | 1 | _ | |a Hamamura, Kengo |0 0000-0001-9146-8554 |b 6 |
| 700 | 1 | _ | |a Katsuyama, Soh |b 7 |
| 700 | 1 | _ | |a Komatsu, Takaaki |b 8 |
| 700 | 1 | _ | |a Morrone, Luigi Antonio |b 9 |
| 700 | 1 | _ | |a Rombolà, Laura |0 0000-0002-1727-3158 |b 10 |
| 700 | 1 | _ | |a Adornetto, Annagrazia |0 0000-0003-1869-2642 |b 11 |
| 700 | 1 | _ | |a Laganà, Annarita S |b 12 |
| 700 | 1 | _ | |a Corasaniti, Maria Tiziana |0 0000-0001-6472-0697 |b 13 |
| 700 | 1 | _ | |a Tonin, Paolo |b 14 |
| 700 | 1 | _ | |a Sakurada, Shinobu |b 15 |
| 700 | 1 | _ | |a Sakurada, Tsukasa |b 16 |
| 700 | 1 | _ | |a Nicotera, Pierluigi |0 P:(DE-2719)2010732 |b 17 |u dzne |
| 700 | 1 | _ | |a Bagetta, Giacinto |0 0000-0001-8540-6218 |b 18 |
| 770 | _ | _ | |a Lipid Nanoparticles in the Treatment of Neurological and Other Aging Related Disorders |
| 773 | _ | _ | |a 10.3390/pharmaceutics13030379 |g Vol. 13, no. 3, p. 379 - |0 PERI:(DE-600)2527217-2 |n 3 |p 379 |t Pharmaceutics |v 13 |y 2021 |x 1999-4923 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/156003/files/DZNE-2021-01135.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/156003/files/DZNE-2021-01135.pdf?subformat=pdfa |
| 909 | C | O | |o oai:pub.dzne.de:156003 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 17 |6 P:(DE-2719)2010732 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-351 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Brain Function |x 0 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-25 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |d 2021-05-04 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-05-04 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-25 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b PHARMACEUTICS : 2021 |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2022-08-24T11:04:26Z |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-05-04 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2022-08-24T11:04:26Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-25 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-25 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2021-05-04 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b PHARMACEUTICS : 2021 |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-05-04 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-25 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2021-05-04 |
| 920 | 1 | _ | |0 I:(DE-2719)5000018 |k AG Nicotera |l Synaptic Connectivity and Neurodegeneration |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)5000018 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|
guest ::