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000156026 0247_ $$2doi$$a10.1007/s00249-021-01515-7
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000156026 037__ $$aDZNE-2021-01158
000156026 041__ $$aEnglish
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000156026 1001_ $$aNajbauer, Eszter E$$b0
000156026 245__ $$aStructure, gating and interactions of the voltage-dependent anion channel.
000156026 260__ $$aNew York$$bSpringer$$c2021
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000156026 520__ $$aThe voltage-dependent anion channel (VDAC) is one of the most highly abundant proteins found in the outer mitochondrial membrane, and was one of the earliest discovered. Here we review progress in understanding VDAC function with a focus on its structure, discussing various models proposed for voltage gating as well as potential drug targets to modulate the channel's function. In addition, we explore the sensitivity of VDAC structure to variations in the membrane environment, comparing DMPC-only, DMPC with cholesterol, and near-native lipid compositions, and use magic-angle spinning NMR spectroscopy to locate cholesterol on the outside of the β-barrel. We find that the VDAC protein structure remains unchanged in different membrane compositions, including conditions with cholesterol.
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000156026 650_7 $$2Other$$aElectrophysiology
000156026 650_7 $$2Other$$aMagic-angle spinning
000156026 650_7 $$2Other$$aMembrane protein
000156026 650_7 $$2Other$$aMolecular dynamics simulations
000156026 650_7 $$2Other$$aSolid-state NMR
000156026 650_7 $$2Other$$aVoltage dependent anion channel
000156026 650_2 $$2MeSH$$aIon Channel Gating
000156026 650_2 $$2MeSH$$aMolecular Dynamics Simulation
000156026 650_2 $$2MeSH$$aVoltage-Dependent Anion Channels: chemistry
000156026 650_2 $$2MeSH$$aVoltage-Dependent Anion Channels: metabolism
000156026 7001_ $$aBecker, Stefan$$b1
000156026 7001_ $$aGiller, Karin$$b2
000156026 7001_ $$0P:(DE-2719)2810591$$aZweckstetter, Markus$$b3$$udzne
000156026 7001_ $$aLange, Adam$$b4
000156026 7001_ $$aSteinem, Claudia$$b5
000156026 7001_ $$ade Groot, Bert L$$b6
000156026 7001_ $$aGriesinger, Christian$$b7
000156026 7001_ $$00000-0003-3216-9065$$aAndreas, Loren B$$b8
000156026 773__ $$0PERI:(DE-600)1398349-0$$a10.1007/s00249-021-01515-7$$gVol. 50, no. 2, p. 159 - 172$$n2$$p159 - 172$$tEuropean biophysics journal$$v50$$x1432-1017$$y2021
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