TY  - JOUR
AU  - Ruppert, Marina C
AU  - Greuel, Andrea
AU  - Freigang, Julia
AU  - Tahmasian, Masoud
AU  - Maier, Franziska
AU  - Hammes, Jochen
AU  - Eimeren, Thilo
AU  - Timmermann, Lars
AU  - Tittgemeyer, Marc
AU  - Drzezga, Alexander
AU  - Eggers, Carsten
TI  - The default mode network and cognition in Parkinson's disease: A multimodal resting-state network approach.
JO  - Human brain mapping
VL  - 42
IS  - 8
SN  - 1097-0193
CY  - New York, NY
PB  - Wiley-Liss
M1  - DZNE-2021-01162
SP  - 2623 - 2641
PY  - 2021
AB  - Involvement of the default mode network (DMN) in cognitive symptoms of Parkinson's disease (PD) has been reported by resting-state functional MRI (rsfMRI) studies. However, the relation to metabolic measures obtained by [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) is largely unknown. We applied multimodal resting-state network analysis to clarify the association between intrinsic metabolic and functional connectivity abnormalities within the DMN and their significance for cognitive symptoms in PD. PD patients were classified into normal cognition (n = 36) and mild cognitive impairment (MCI; n = 12). The DMN was identified by applying an independent component analysis to FDG-PET and rsfMRI data of a matched subset (16 controls and 16 PD patients) of the total cohort. Besides metabolic activity, metabolic and functional connectivity within the DMN were compared between the patients' groups and healthy controls (n = 16). Glucose metabolism was significantly reduced in all DMN nodes in both patient groups compared to controls, with the lowest uptake in PD-MCI (p < .05). Increased metabolic and functional connectivity along fronto-parietal connections was identified in PD-MCI patients compared to controls and unimpaired patients. Functional connectivity negatively correlated with cognitive composite z-scores in patients (r = -.43, p = .005). The current study clarifies the commonalities of metabolic and hemodynamic measures of brain network activity and their individual significance for cognitive symptoms in PD, highlighting the added value of multimodal resting-state network approaches for identifying prospective biomarkers.
KW  - Aged
KW  - Cerebral Cortex: diagnostic imaging
KW  - Cerebral Cortex: metabolism
KW  - Cerebral Cortex: physiopathology
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: metabolism
KW  - Cognitive Dysfunction: physiopathology
KW  - Connectome
KW  - Default Mode Network: diagnostic imaging
KW  - Default Mode Network: metabolism
KW  - Default Mode Network: physiopathology
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Multimodal Imaging
KW  - Parkinson Disease: complications
KW  - Parkinson Disease: diagnostic imaging
KW  - Parkinson Disease: metabolism
KW  - Parkinson Disease: physiopathology
KW  - Positron-Emission Tomography
KW  - Parkinson's disease (Other)
KW  - [18F]-FDG-PET (Other)
KW  - default mode network (Other)
KW  - metabolic covariance (Other)
KW  - mild cognitive impairment (Other)
KW  - resting-state fMRI (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33638213
C2  - pmc:PMC8090788
DO  - DOI:10.1002/hbm.25393
UR  - https://pub.dzne.de/record/156030
ER  -