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000157719 037__ $$aDZNE-2021-01176
000157719 041__ $$aEnglish
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000157719 1001_ $$0P:(DE-2719)9001564$$aIchwan, Muhammad$$b0$$udzne
000157719 245__ $$aApple Peel and Flesh Contain Pro-neurogenic Compounds.
000157719 260__ $$a[New York, NY]$$bElsevier$$c2021
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000157719 520__ $$aAs mammals evolved with exposure to particular diets, naturally abundant compounds may have become part of the set of environmental co-determinants that shaped brain structure and function. Here we investigated whether bioactive factors found in apples directly affect hippocampal neurogenesis in the adult mouse. We found that quercetin, the most abundant flavanol in apple peel, was anti-proliferative at high concentrations but pro-neurogenic at low concentrations. This was confirmed in vivo, with intraperitoneally delivered quercetin promoting survival and neuronal differentiation, without affecting proliferation. Using a bioassay-guided fractionation approach we also identified additional pro-neurogenic compounds in apple flesh that were not related to flavonoids. We found that 3,5-dihydroxybenzoic acid significantly increased neural precursor cell proliferation and neurogenesis. This work shows that both flavonoids and 3,5-dihydroxybenzoic acid are pro-neurogenic, not only by activating precursor cell proliferation but also by promoting cell-cycle exit, cellular survival, and neuronal differentiation.
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000157719 650_7 $$2Other$$a3,5-dihydroxybenzoic acid
000157719 650_7 $$2Other$$aadult neurogenesis
000157719 650_7 $$2Other$$adentate gyrus
000157719 650_7 $$2Other$$ahippocampus
000157719 650_7 $$2Other$$amouse
000157719 650_7 $$2Other$$aneural precursor cells
000157719 650_7 $$2Other$$aquercetin
000157719 650_2 $$2MeSH$$aAnimals
000157719 650_2 $$2MeSH$$aAntioxidants: pharmacology
000157719 650_2 $$2MeSH$$aCell Cycle: drug effects
000157719 650_2 $$2MeSH$$aCell Differentiation: drug effects
000157719 650_2 $$2MeSH$$aCell Proliferation: drug effects
000157719 650_2 $$2MeSH$$aCell Survival: drug effects
000157719 650_2 $$2MeSH$$aFemale
000157719 650_2 $$2MeSH$$aFlavonoids: pharmacology
000157719 650_2 $$2MeSH$$aFruit: chemistry
000157719 650_2 $$2MeSH$$aHippocampus: drug effects
000157719 650_2 $$2MeSH$$aHydroxybenzoates: pharmacology
000157719 650_2 $$2MeSH$$aMale
000157719 650_2 $$2MeSH$$aMalus: chemistry
000157719 650_2 $$2MeSH$$aMice
000157719 650_2 $$2MeSH$$aMice, Inbred C57BL
000157719 650_2 $$2MeSH$$aNeurogenesis: drug effects
000157719 650_2 $$2MeSH$$aProto-Oncogene Proteins c-akt: metabolism
000157719 650_2 $$2MeSH$$aQuercetin: pharmacology
000157719 650_2 $$2MeSH$$aReceptors, G-Protein-Coupled: metabolism
000157719 650_2 $$2MeSH$$aResorcinols: pharmacology
000157719 650_2 $$2MeSH$$aSignal Transduction
000157719 7001_ $$0P:(DE-2719)9000335$$aWalker, Tara L$$b1
000157719 7001_ $$0P:(DE-2719)2810764$$aNicola, Zeina$$b2
000157719 7001_ $$aLudwig-Müller, Jutta$$b3
000157719 7001_ $$aBöttcher, Christoph$$b4
000157719 7001_ $$0P:(DE-2719)2812530$$aOverall, Rupert W$$b5
000157719 7001_ $$0P:(DE-2719)2810887$$aAdusumilli, Vijay S$$b6
000157719 7001_ $$0P:(DE-2719)9001565$$aBulut, Merve$$b7$$udzne
000157719 7001_ $$aSykes, Alex M$$b8
000157719 7001_ $$aHübner, Norbert$$b9
000157719 7001_ $$aRamirez-Rodriguez, Gerardo$$b10
000157719 7001_ $$aOrtiz-López, Leonardo$$b11
000157719 7001_ $$aLugo-Hernández, Enrique A$$b12
000157719 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b13$$eLast author
000157719 773__ $$0PERI:(DE-600)2720528-9$$a10.1016/j.stemcr.2021.01.005$$gVol. 16, no. 3, p. 548 - 565$$n3$$p548 - 565$$tStem cell reports$$v16$$x2213-6711$$y2021
000157719 8564_ $$uhttps://www.sciencedirect.com/science/article/pii/S2213671121000357?via%3Dihub
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