TY  - JOUR
AU  - Pietrowski, Marie J
AU  - Gabr, Amrq
AU  - Kozlov, Stanislav
AU  - Blum, David
AU  - Halle, Annett
AU  - Carvalho, Kevin
TI  - Glial Purinergic Signaling in Neurodegeneration.
JO  - Frontiers in neurology
VL  - 12
SN  - 1664-2295
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2021-01189
SP  - 654850
PY  - 2021
AB  - Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-specific expression patterns of purinergic signaling components change in neurodegeneration and how dysregulated glial purinergic signaling and crosstalk may contribute to disease pathophysiology, thus bearing promising potential for the development of new therapeutical options for neurodegenerative diseases.
KW  - ATP (Other)
KW  - Alzheimer (Other)
KW  - adenosine (Other)
KW  - astrocyte (Other)
KW  - microglia (Other)
KW  - neurodegeneration (Other)
KW  - oligodendrocyte (Other)
KW  - purine (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34054698
C2  - pmc:PMC8160300
DO  - DOI:10.3389/fneur.2021.654850
UR  - https://pub.dzne.de/record/157732
ER  -