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@ARTICLE{Pietrowski:157732,
      author       = {Pietrowski, Marie J and Gabr, Amrq and Kozlov, Stanislav
                      and Blum, David and Halle, Annett and Carvalho, Kevin},
      title        = {{G}lial {P}urinergic {S}ignaling in {N}eurodegeneration.},
      journal      = {Frontiers in neurology},
      volume       = {12},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2021-01189},
      pages        = {654850},
      year         = {2021},
      abstract     = {Purinergic signaling regulates neuronal and glial cell
                      functions in the healthy CNS. In neurodegenerative diseases,
                      purinergic signaling becomes dysregulated and can affect
                      disease-associated phenotypes of glial cells. In this
                      review, we discuss how cell-specific expression patterns of
                      purinergic signaling components change in neurodegeneration
                      and how dysregulated glial purinergic signaling and
                      crosstalk may contribute to disease pathophysiology, thus
                      bearing promising potential for the development of new
                      therapeutical options for neurodegenerative diseases.},
      subtyp        = {Review Article},
      keywords     = {ATP (Other) / Alzheimer (Other) / adenosine (Other) /
                      astrocyte (Other) / microglia (Other) / neurodegeneration
                      (Other) / oligodendrocyte (Other) / purine (Other)},
      cin          = {AG Halle},
      ddc          = {610},
      cid          = {I:(DE-2719)1013034},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34054698},
      pmc          = {pmc:PMC8160300},
      doi          = {10.3389/fneur.2021.654850},
      url          = {https://pub.dzne.de/record/157732},
}