000157739 001__ 157739
000157739 005__ 20230915092352.0
000157739 0247_ $$2doi$$a10.3389/fimmu.2021.652470
000157739 0247_ $$2pmid$$apmid:33841435
000157739 0247_ $$2pmc$$apmc:PMC8027077
000157739 0247_ $$2altmetric$$aaltmetric:102734480
000157739 037__ $$aDZNE-2021-01196
000157739 041__ $$aEnglish
000157739 082__ $$a610
000157739 1001_ $$0P:(DE-2719)9000843$$aReusch, Nico$$b0$$eFirst author$$udzne
000157739 245__ $$aNeutrophils in COVID-19.
000157739 260__ $$aLausanne$$bFrontiers Media$$c2021
000157739 3367_ $$2DRIVER$$aarticle
000157739 3367_ $$2DataCite$$aOutput Types/Journal article
000157739 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1632221530_9134$$xReview Article
000157739 3367_ $$2BibTeX$$aARTICLE
000157739 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000157739 3367_ $$00$$2EndNote$$aJournal Article
000157739 520__ $$aStrong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses. While originally considered to be a rather homogeneous cell type, recent attention to neutrophils has uncovered their fascinating transcriptional and functional diversity as well as their developmental trajectories. These new findings are important to better understand the many facets of neutrophil involvement not only in COVID-19 but also many other acute or chronic inflammatory diseases, both communicable and non-communicable. Here, we highlight the observed immune deviation of neutrophils in COVID-19 and summarize several promising therapeutic attempts to precisely target neutrophils and their reactivity in patients with COVID-19.
000157739 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
000157739 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000157739 650_7 $$2Other$$aCOVID-19
000157739 650_7 $$2Other$$aSARS-CoV-2
000157739 650_7 $$2Other$$aclinical trials
000157739 650_7 $$2Other$$agranulocytes
000157739 650_7 $$2Other$$aneutrophils
000157739 650_7 $$2Other$$ascRNA-seq
000157739 650_7 $$2Other$$aviral infection
000157739 650_2 $$2MeSH$$aCOVID-19: epidemiology
000157739 650_2 $$2MeSH$$aCOVID-19: immunology
000157739 650_2 $$2MeSH$$aHumans
000157739 650_2 $$2MeSH$$aNeutrophils: immunology
000157739 650_2 $$2MeSH$$aPandemics
000157739 650_2 $$2MeSH$$aSARS-CoV-2: immunology
000157739 7001_ $$0P:(DE-2719)9000846$$aDe Domenico, Elena$$b1$$udzne
000157739 7001_ $$0P:(DE-2719)9001512$$aBonaguro, Lorenzo$$b2$$udzne
000157739 7001_ $$0P:(DE-2719)9001500$$aSchulte-Schrepping, Jonas$$b3$$udzne
000157739 7001_ $$0P:(DE-2719)9000836$$aBaßler, Kevin$$b4$$udzne
000157739 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b5$$udzne
000157739 7001_ $$0P:(DE-2719)2812913$$aAschenbrenner, Anna Christin$$b6$$eLast author$$udzne
000157739 773__ $$0PERI:(DE-600)2606827-8$$a10.3389/fimmu.2021.652470$$gVol. 12, p. 652470$$p652470$$tFrontiers in immunology$$v12$$x1664-3224$$y2021
000157739 8564_ $$uhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.652470/full
000157739 8564_ $$uhttps://pub.dzne.de/record/157739/files/19422.pdf$$yOpenAccess
000157739 8564_ $$uhttps://pub.dzne.de/record/157739/files/19422.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000157739 909CO $$ooai:pub.dzne.de:157739$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000157739 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000843$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000157739 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000846$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000157739 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001512$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000157739 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001500$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000157739 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000836$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000157739 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811660$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000157739 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812913$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000157739 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x0
000157739 9141_ $$y2021
000157739 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-01-29
000157739 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-29
000157739 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-29
000157739 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-01-29
000157739 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000157739 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-01-29
000157739 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT IMMUNOL : 2021$$d2022-11-23
000157739 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-23
000157739 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-23
000157739 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-05-11T10:28:02Z
000157739 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-05-11T10:28:02Z
000157739 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-05-11T10:28:02Z
000157739 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-23
000157739 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-23
000157739 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bFRONT IMMUNOL : 2021$$d2022-11-23
000157739 9201_ $$0I:(DE-2719)1013031$$kSchultze - PRECISE$$lUnited epigenomic platform$$x0
000157739 980__ $$ajournal
000157739 980__ $$aVDB
000157739 980__ $$aUNRESTRICTED
000157739 980__ $$aI:(DE-2719)5000031
000157739 9801_ $$aFullTexts