TY  - JOUR
AU  - Reusch, Nico
AU  - De Domenico, Elena
AU  - Bonaguro, Lorenzo
AU  - Schulte-Schrepping, Jonas
AU  - Baßler, Kevin
AU  - Schultze, Joachim L
AU  - Aschenbrenner, Anna Christin
TI  - Neutrophils in COVID-19.
JO  - Frontiers in immunology
VL  - 12
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2021-01196
SP  - 652470
PY  - 2021
AB  - Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses. While originally considered to be a rather homogeneous cell type, recent attention to neutrophils has uncovered their fascinating transcriptional and functional diversity as well as their developmental trajectories. These new findings are important to better understand the many facets of neutrophil involvement not only in COVID-19 but also many other acute or chronic inflammatory diseases, both communicable and non-communicable. Here, we highlight the observed immune deviation of neutrophils in COVID-19 and summarize several promising therapeutic attempts to precisely target neutrophils and their reactivity in patients with COVID-19.
KW  - COVID-19: epidemiology
KW  - COVID-19: immunology
KW  - Humans
KW  - Neutrophils: immunology
KW  - Pandemics
KW  - SARS-CoV-2: immunology
KW  - COVID-19 (Other)
KW  - SARS-CoV-2 (Other)
KW  - clinical trials (Other)
KW  - granulocytes (Other)
KW  - neutrophils (Other)
KW  - scRNA-seq (Other)
KW  - viral infection (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33841435
C2  - pmc:PMC8027077
DO  - DOI:10.3389/fimmu.2021.652470
UR  - https://pub.dzne.de/record/157739
ER  -