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000157752 0247_ $$2doi$$a10.1016/j.stemcr.2021.03.008
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000157752 037__ $$aDZNE-2021-01209
000157752 041__ $$aEnglish
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000157752 1001_ $$aUlmke, Pauline Antonie$$b0
000157752 245__ $$aMolecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.
000157752 260__ $$a[New York, NY]$$bElsevier$$c2021
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000157752 520__ $$aIntermediate progenitor cells (IPCs) are neocortical neuronal precursors. Although IPCs play crucial roles in corticogenesis, their molecular features remain largely unknown. In this study, we aimed to characterize the molecular profile of IPCs. We isolated TBR2-positive (+) IPCs and TBR2-negative (-) cell populations in the developing mouse cortex. Comparative genome-wide gene expression analysis of TBR2+ IPCs versus TBR2- cells revealed differences in key factors involved in chromatid segregation, cell-cycle regulation, transcriptional regulation, and cell signaling. Notably, mutation of many IPC genes in human has led to intellectual disability and caused a wide range of cortical malformations, including microcephaly and agenesis of corpus callosum. Loss-of-function experiments in cortex-specific mutants of Esco2, one of the novel IPC genes, demonstrate its critical role in IPC maintenance, and substantiate the identification of a central genetic determinant of IPC biogenesis. Our data provide novel molecular characteristics of IPCs in the developing mouse cortex.
000157752 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
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000157752 650_7 $$2Other$$aESCO2
000157752 650_7 $$2Other$$aTBR2
000157752 650_7 $$2Other$$aapoptosis
000157752 650_7 $$2Other$$acell-cycle regulation
000157752 650_7 $$2Other$$achromosome segregation
000157752 650_7 $$2Other$$acortical development
000157752 650_7 $$2Other$$acortical malformation
000157752 650_7 $$2Other$$aintermediate progenitor cells
000157752 650_7 $$2Other$$asignaling pathways
000157752 650_7 $$2Other$$atranscription factors
000157752 650_7 $$2Other$$atranscriptome
000157752 650_2 $$2MeSH$$aAcetyltransferases: genetics
000157752 650_2 $$2MeSH$$aAcetyltransferases: metabolism
000157752 650_2 $$2MeSH$$aAnimals
000157752 650_2 $$2MeSH$$aApoptosis: genetics
000157752 650_2 $$2MeSH$$aCerebral Cortex: cytology
000157752 650_2 $$2MeSH$$aCerebral Cortex: embryology
000157752 650_2 $$2MeSH$$aChromatids: metabolism
000157752 650_2 $$2MeSH$$aChromosome Segregation: genetics
000157752 650_2 $$2MeSH$$aGene Expression Profiling
000157752 650_2 $$2MeSH$$aGene Expression Regulation
000157752 650_2 $$2MeSH$$aHumans
000157752 650_2 $$2MeSH$$aMice
000157752 650_2 $$2MeSH$$aMitosis: genetics
000157752 650_2 $$2MeSH$$aMutation: genetics
000157752 650_2 $$2MeSH$$aNeural Stem Cells: cytology
000157752 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000157752 650_2 $$2MeSH$$aNeurodevelopmental Disorders: genetics
000157752 650_2 $$2MeSH$$aNeurodevelopmental Disorders: pathology
000157752 650_2 $$2MeSH$$aSignal Transduction
000157752 7001_ $$0P:(DE-2719)2812054$$aSakib, M Sadman$$b1$$udzne
000157752 7001_ $$aDitte, Peter$$b2
000157752 7001_ $$aSokpor, Godwin$$b3
000157752 7001_ $$0P:(DE-2719)2812366$$aKerimoglu, Cemil$$b4$$udzne
000157752 7001_ $$aPham, Linh$$b5
000157752 7001_ $$aXie, Yuanbin$$b6
000157752 7001_ $$aMao, Xiaoyi$$b7
000157752 7001_ $$aRosenbusch, Joachim$$b8
000157752 7001_ $$aTeichmann, Ulrike$$b9
000157752 7001_ $$aNguyen, Huu Phuc$$b10
000157752 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b11$$udzne
000157752 7001_ $$aEichele, Gregor$$b12
000157752 7001_ $$aStaiger, Jochen F$$b13
000157752 7001_ $$aTuoc, Tran$$b14
000157752 773__ $$0PERI:(DE-600)2720528-9$$a10.1016/j.stemcr.2021.03.008$$gVol. 16, no. 4, p. 968 - 984$$n4$$p968 - 984$$tStem cell reports$$v16$$x2213-6711$$y2021
000157752 8564_ $$uhttps://pub.dzne.de/record/157752/files/DZNE-2021-01209.pdf$$yOpenAccess
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