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@ARTICLE{Ulmke:157752,
      author       = {Ulmke, Pauline Antonie and Sakib, M Sadman and Ditte, Peter
                      and Sokpor, Godwin and Kerimoglu, Cemil and Pham, Linh and
                      Xie, Yuanbin and Mao, Xiaoyi and Rosenbusch, Joachim and
                      Teichmann, Ulrike and Nguyen, Huu Phuc and Fischer, Andre
                      and Eichele, Gregor and Staiger, Jochen F and Tuoc, Tran},
      title        = {{M}olecular {P}rofiling {R}eveals {I}nvolvement of {ESCO}2
                      in {I}ntermediate {P}rogenitor {C}ell {M}aintenance in the
                      {D}eveloping {M}ouse {C}ortex.},
      journal      = {Stem cell reports},
      volume       = {16},
      number       = {4},
      issn         = {2213-6711},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-01209},
      pages        = {968 - 984},
      year         = {2021},
      abstract     = {Intermediate progenitor cells (IPCs) are neocortical
                      neuronal precursors. Although IPCs play crucial roles in
                      corticogenesis, their molecular features remain largely
                      unknown. In this study, we aimed to characterize the
                      molecular profile of IPCs. We isolated TBR2-positive (+)
                      IPCs and TBR2-negative (-) cell populations in the
                      developing mouse cortex. Comparative genome-wide gene
                      expression analysis of TBR2+ IPCs versus TBR2- cells
                      revealed differences in key factors involved in chromatid
                      segregation, cell-cycle regulation, transcriptional
                      regulation, and cell signaling. Notably, mutation of many
                      IPC genes in human has led to intellectual disability and
                      caused a wide range of cortical malformations, including
                      microcephaly and agenesis of corpus callosum.
                      Loss-of-function experiments in cortex-specific mutants of
                      Esco2, one of the novel IPC genes, demonstrate its critical
                      role in IPC maintenance, and substantiate the identification
                      of a central genetic determinant of IPC biogenesis. Our data
                      provide novel molecular characteristics of IPCs in the
                      developing mouse cortex.},
      keywords     = {Acetyltransferases: genetics / Acetyltransferases:
                      metabolism / Animals / Apoptosis: genetics / Cerebral
                      Cortex: cytology / Cerebral Cortex: embryology / Chromatids:
                      metabolism / Chromosome Segregation: genetics / Gene
                      Expression Profiling / Gene Expression Regulation / Humans /
                      Mice / Mitosis: genetics / Mutation: genetics / Neural Stem
                      Cells: cytology / Neural Stem Cells: metabolism /
                      Neurodevelopmental Disorders: genetics / Neurodevelopmental
                      Disorders: pathology / Signal Transduction / ESCO2 (Other) /
                      TBR2 (Other) / apoptosis (Other) / cell-cycle regulation
                      (Other) / chromosome segregation (Other) / cortical
                      development (Other) / cortical malformation (Other) /
                      intermediate progenitor cells (Other) / signaling pathways
                      (Other) / transcription factors (Other) / transcriptome
                      (Other)},
      cin          = {AG Fischer},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33798452},
      pmc          = {pmc:PMC8072132},
      doi          = {10.1016/j.stemcr.2021.03.008},
      url          = {https://pub.dzne.de/record/157752},
}