Home > Publications Database > Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. > print

001     157752
005     20240302115203.0
024 7 _ |a 10.1016/j.stemcr.2021.03.008
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037 _ _ |a DZNE-2021-01209
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Ulmke, Pauline Antonie
|b 0
245 _ _ |a Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.
260 _ _ |a [New York, NY]
|c 2021
|b Elsevier
336 7 _ |a article
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520 _ _ |a Intermediate progenitor cells (IPCs) are neocortical neuronal precursors. Although IPCs play crucial roles in corticogenesis, their molecular features remain largely unknown. In this study, we aimed to characterize the molecular profile of IPCs. We isolated TBR2-positive (+) IPCs and TBR2-negative (-) cell populations in the developing mouse cortex. Comparative genome-wide gene expression analysis of TBR2+ IPCs versus TBR2- cells revealed differences in key factors involved in chromatid segregation, cell-cycle regulation, transcriptional regulation, and cell signaling. Notably, mutation of many IPC genes in human has led to intellectual disability and caused a wide range of cortical malformations, including microcephaly and agenesis of corpus callosum. Loss-of-function experiments in cortex-specific mutants of Esco2, one of the novel IPC genes, demonstrate its critical role in IPC maintenance, and substantiate the identification of a central genetic determinant of IPC biogenesis. Our data provide novel molecular characteristics of IPCs in the developing mouse cortex.
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650 _ 7 |a ESCO2
|2 Other
650 _ 7 |a TBR2
|2 Other
650 _ 7 |a apoptosis
|2 Other
650 _ 7 |a cell-cycle regulation
|2 Other
650 _ 7 |a chromosome segregation
|2 Other
650 _ 7 |a cortical development
|2 Other
650 _ 7 |a cortical malformation
|2 Other
650 _ 7 |a intermediate progenitor cells
|2 Other
650 _ 7 |a signaling pathways
|2 Other
650 _ 7 |a transcription factors
|2 Other
650 _ 7 |a transcriptome
|2 Other
650 _ 2 |a Acetyltransferases: genetics
|2 MeSH
650 _ 2 |a Acetyltransferases: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Apoptosis: genetics
|2 MeSH
650 _ 2 |a Cerebral Cortex: cytology
|2 MeSH
650 _ 2 |a Cerebral Cortex: embryology
|2 MeSH
650 _ 2 |a Chromatids: metabolism
|2 MeSH
650 _ 2 |a Chromosome Segregation: genetics
|2 MeSH
650 _ 2 |a Gene Expression Profiling
|2 MeSH
650 _ 2 |a Gene Expression Regulation
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mitosis: genetics
|2 MeSH
650 _ 2 |a Mutation: genetics
|2 MeSH
650 _ 2 |a Neural Stem Cells: cytology
|2 MeSH
650 _ 2 |a Neural Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Neurodevelopmental Disorders: genetics
|2 MeSH
650 _ 2 |a Neurodevelopmental Disorders: pathology
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
700 1 _ |a Sakib, M Sadman
|0 P:(DE-2719)2812054
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700 1 _ |a Ditte, Peter
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700 1 _ |a Sokpor, Godwin
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700 1 _ |a Kerimoglu, Cemil
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700 1 _ |a Pham, Linh
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700 1 _ |a Xie, Yuanbin
|b 6
700 1 _ |a Mao, Xiaoyi
|b 7
700 1 _ |a Rosenbusch, Joachim
|b 8
700 1 _ |a Teichmann, Ulrike
|b 9
700 1 _ |a Nguyen, Huu Phuc
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700 1 _ |a Fischer, Andre
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700 1 _ |a Eichele, Gregor
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700 1 _ |a Staiger, Jochen F
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700 1 _ |a Tuoc, Tran
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773 _ _ |a 10.1016/j.stemcr.2021.03.008
|g Vol. 16, no. 4, p. 968 - 984
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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