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@ARTICLE{Naasan:157757,
      author       = {Naasan, Georges and Shdo, Suzanne M and Morenas Rodriguez,
                      Estrella and Spina, Salvatore and Grinberg, Lea and Lopez,
                      Lucia and Karydas, Anna and Seeley, William W and Miller,
                      Bruce L and Rankin, Katherine P},
      title        = {{P}sychosis in neurodegenerative disease: differential
                      patterns of hallucination and delusion symptoms.},
      journal      = {Brain},
      volume       = {144},
      number       = {3},
      issn         = {1460-2156},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2021-01214},
      pages        = {999 - 1012},
      year         = {2021},
      abstract     = {Although psychosis is a defining feature of Lewy body
                      disease, psychotic symptoms occur in a subset of patients
                      with every major neurodegenerative disease. Few studies,
                      however, have compared disease-related rates of psychosis
                      prevalence in a large autopsy-based cohort, and it remains
                      unclear how diseases differ with respect to the nature or
                      content of the psychosis. We conducted a retrospective chart
                      review of 372 patients with autopsy-confirmed
                      neurodegenerative pathology: 111 with Alzheimer's disease,
                      59 with Lewy body disease and concomitant Alzheimer's
                      disease, 133 with frontotemporal lobar degeneration (FTLD)
                      with tau inclusions (including progressive supranuclear
                      palsy, corticobasal degeneration or Pick's disease), and 69
                      with FTLD and TDP inclusions (FTLD-TDP, including types
                      A-C). Psychosis content was classified by subtype, and the
                      frequency of each subtype was compared among pathological
                      diagnoses using logistic regression. A total of 111 of 372
                      patients had psychosis. Compared to other groups, patients
                      with Lewy body disease/Alzheimer's disease pathology were
                      significantly more likely to have hallucinations and were
                      more likely to have more than one subtype of hallucination.
                      Patients with Braak Parkinson stage 5-6 Lewy body disease
                      were significantly more likely than those with no Lewy body
                      disease to have visual hallucinations of misperception,
                      peripheral hallucinations, hallucinations that moved,
                      hallucinations of people/animals/objects, as well as
                      delusions regarding a place and delusions of
                      misidentification. The feeling of a presence occurred
                      significantly more frequently in patients with Lewy body
                      disease/Alzheimer's disease than all other pathologies.
                      Patients with FTLD-TDP were significantly more likely to
                      have delusions, and for the delusions to occur in the first
                      3 years of the disease, when compared to patients with
                      Alzheimer's disease and FTLD-tau, though rates were not
                      significantly greater than patients with Lewy body
                      disease/Alzheimer's disease. Paranoia occurred more
                      frequently in the FTLD-TDP and Lewy body disease/Alzheimer's
                      disease categories compared to patients with Alzheimer's
                      disease or FTLD-tau. Patients with FTLD-TDP pathology had
                      delusions of misidentification as frequently as patients
                      with Lewy body disease/Alzheimer's disease, and were
                      significantly more likely to have self-elevating delusions
                      such as grandiosity and erotomania compared to patients with
                      other pathologies including FTLD-tau. These data show that
                      the nature and content of psychosis can provide meaningful
                      information about the underlying neurodegenerative
                      pathology, emphasizing the importance of characterizing
                      patients' psychoses for prediction of the neuropathological
                      diagnosis, regardless of a patient's clinical syndrome.},
      keywords     = {Aged / Delusions: epidemiology / Delusions: etiology /
                      Female / Hallucinations: epidemiology / Hallucinations:
                      etiology / Humans / Male / Middle Aged / Neurodegenerative
                      Diseases: complications / Prevalence / Psychotic Disorders:
                      epidemiology / Psychotic Disorders: etiology / Lewy body
                      disease (Other) / TDP-43 (Other) / frontotemporal dementia
                      (Other) / pathology (Other) / psychosis (Other)},
      cin          = {AG Haass old},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33501939},
      pmc          = {pmc:PMC8041322},
      doi          = {10.1093/brain/awaa413},
      url          = {https://pub.dzne.de/record/157757},
}