TY  - JOUR
AU  - Raposo, N.
AU  - Zanon Zotin, M. C.
AU  - Schoemaker, D.
AU  - Xiong, L.
AU  - Fotiadis, P.
AU  - Charidimou, A.
AU  - Pasi, M.
AU  - Boulouis, G.
AU  - Schwab, K.
AU  - Schirmer, Markus Dieter
AU  - Etherton, Mark R.
AU  - Gurol, M. E.
AU  - Greenberg, S. M.
AU  - Duering, M.
AU  - Viswanathan, Vivekanandhan
TI  - Peak Width of Skeletonized Mean Diffusivity as Neuroimaging Biomarker in Cerebral Amyloid Angiopathy.
JO  - American journal of neuroradiology
VL  - 42
IS  - 5
SN  - 1936-959X
CY  - Oak Brook, Ill.
PB  - Soc.
M1  - DZNE-2021-01236
SP  - 875 - 881
PY  - 2021
AB  - Whole-brain network connectivity has been shown to be a useful biomarker of cerebral amyloid angiopathy and related cognitive impairment. We evaluated an automated DTI-based method, peak width of skeletonized mean diffusivity, in cerebral amyloid angiopathy, together with its association with conventional MRI markers and cognitive functions.We included 24 subjects (mean age, 74.7 [SD, 6.0] years) with probable cerebral amyloid angiopathy and mild cognitive impairment and 62 patients with MCI not attributable to cerebral amyloid angiopathy (non-cerebral amyloid angiopathy-mild cognitive impairment). We compared peak width of skeletonized mean diffusivity between subjects with cerebral amyloid angiopathy-mild cognitive impairment and non-cerebral amyloid angiopathy-mild cognitive impairment and explored its associations with cognitive functions and conventional markers of cerebral small-vessel disease, using linear regression models.Subjects with Cerebral amyloid angiopathy-mild cognitive impairment showed increased peak width of skeletonized mean diffusivity in comparison to those with non-cerebral amyloid angiopathy-mild cognitive impairment (P < .001). Peak width of skeletonized mean diffusivity values were correlated with the volume of white matter hyperintensities in both groups. Higher peak width of skeletonized mean diffusivity was associated with worse performance in processing speed among patients with cerebral amyloid angiopathy, after adjusting for other MRI markers of cerebral small vessel disease. The peak width of skeletonized mean diffusivity did not correlate with cognitive functions among those with non-cerebral amyloid angiopathy-mild cognitive impairment.Peak width of skeletonized mean diffusivity is altered in cerebral amyloid angiopathy and is associated with performance in processing speed. This DTI-based method may reflect the degree of white matter structural disruption in cerebral amyloid angiopathy and could be a useful biomarker for cognition in this population.
KW  - Aged
KW  - Aged, 80 and over
KW  - Biomarkers
KW  - Cerebral Amyloid Angiopathy: diagnostic imaging
KW  - Cerebral Amyloid Angiopathy: psychology
KW  - Cerebral Small Vessel Diseases: diagnostic imaging
KW  - Cognition
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: psychology
KW  - Diffusion Magnetic Resonance Imaging
KW  - Diffusion Tensor Imaging: methods
KW  - Female
KW  - Humans
KW  - Image Processing, Computer-Assisted: methods
KW  - Male
KW  - Neuroimaging
KW  - Psychomotor Performance
KW  - Reaction Time
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:33664113
C2  - pmc:PMC8115367
DO  - DOI:10.3174/ajnr.A7042
UR  - https://pub.dzne.de/record/157779
ER  -