%0 Journal Article
%A Kessler, Christoph
%A Serna-Higuita, Lina M
%A Rattay, Tim W
%A Maetzler, Walter
%A Wurster, Isabel
%A Hayer, Stefanie
%A Wilke, Carlo
%A Hengel, Holger
%A Reichbauer, Jennifer
%A Armbruster, Marcel
%A Schöls, Ludger
%A Martus, Peter
%A Schüle-Freyer, Rebecca
%T Neurofilament light chain is a cerebrospinal fluid biomarker in hereditary spastic paraplegia.
%J Annals of Clinical and Translational Neurology
%V 8
%N 5
%@ 2328-9503
%C Chichester [u.a.]
%I Wiley
%M DZNE-2021-01264
%P 1122 - 1131
%D 2021
%Z CC BY-NC-ND
%X Despite the need for diagnostics and research, data on fluid biomarkers in hereditary spastic paraplegia (HSP) are scarce. We, therefore, explore Neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of patients with hereditary spastic paraplegia and provide information on the influence of demographic factors.The study recruited 59 HSP cases (33 genetically confirmed) and 59 controls matched in age and sex. Neurofilament light chain levels were assessed by enzyme-linked immunosorbent assay. The statistical analysis included the effects of age, sex, and genetic status (confirmed vs. not confirmed).Levels of CSF NfL were significantly increased in patients with hereditary spastic paraplegia compared to controls (median 741 pg/mL vs. 387 pg/mL, p < 0.001). Age (1.4
%K Adolescent
%K Adult
%K Age Factors
%K Aged
%K Biomarkers: cerebrospinal fluid
%K Cross-Sectional Studies
%K Female
%K Humans
%K Male
%K Middle Aged
%K Neurofilament Proteins: cerebrospinal fluid
%K Sex Factors
%K Spastic Paraplegia, Hereditary: cerebrospinal fluid
%K Spastic Paraplegia, Hereditary: diagnosis
%K Young Adult
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33819388
%2 pmc:PMC8108414
%R 10.1002/acn3.51358
%U https://pub.dzne.de/record/157807