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000157807 1001_ $$0P:(DE-2719)9000957$$aKessler, Christoph$$b0$$eFirst author$$udzne
000157807 245__ $$aNeurofilament light chain is a cerebrospinal fluid biomarker in hereditary spastic paraplegia.
000157807 260__ $$aChichester [u.a.]$$bWiley$$c2021
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000157807 520__ $$aDespite the need for diagnostics and research, data on fluid biomarkers in hereditary spastic paraplegia (HSP) are scarce. We, therefore, explore Neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of patients with hereditary spastic paraplegia and provide information on the influence of demographic factors.The study recruited 59 HSP cases (33 genetically confirmed) and 59 controls matched in age and sex. Neurofilament light chain levels were assessed by enzyme-linked immunosorbent assay. The statistical analysis included the effects of age, sex, and genetic status (confirmed vs. not confirmed).Levels of CSF NfL were significantly increased in patients with hereditary spastic paraplegia compared to controls (median 741 pg/mL vs. 387 pg/mL, p < 0.001). Age (1.4% annual increase) and male sex (81% increase) impacted CSF NfL levels in patients. The age-dependent increase of CSF NfL levels was steeper in controls (2.6% annual increase). Thus, the CSF NfL ratio of patients and matched controls-expressing patients' fold increases in CSF NfL-declined considerably with age.CSF NfL is a reliable cross-sectional biomarker in hereditary spastic paraplegia. Sex is a relevant factor to consider, as male patients have remarkably higher CSF NfL levels. While levels also increase with age, the gap between patients and controls is narrowing in older subjects. This indicates distinct temporal dynamics of CSF NfL in patients with hereditary spastic paraplegia, with a rise around phenotypic conversion and comparatively static levels afterward.
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000157807 650_2 $$2MeSH$$aAdolescent
000157807 650_2 $$2MeSH$$aAdult
000157807 650_2 $$2MeSH$$aAge Factors
000157807 650_2 $$2MeSH$$aAged
000157807 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000157807 650_2 $$2MeSH$$aCross-Sectional Studies
000157807 650_2 $$2MeSH$$aFemale
000157807 650_2 $$2MeSH$$aHumans
000157807 650_2 $$2MeSH$$aMale
000157807 650_2 $$2MeSH$$aMiddle Aged
000157807 650_2 $$2MeSH$$aNeurofilament Proteins: cerebrospinal fluid
000157807 650_2 $$2MeSH$$aSex Factors
000157807 650_2 $$2MeSH$$aSpastic Paraplegia, Hereditary: cerebrospinal fluid
000157807 650_2 $$2MeSH$$aSpastic Paraplegia, Hereditary: diagnosis
000157807 650_2 $$2MeSH$$aYoung Adult
000157807 7001_ $$aSerna-Higuita, Lina M$$b1
000157807 7001_ $$0P:(DE-2719)2811827$$aRattay, Tim W$$b2$$udzne
000157807 7001_ $$0P:(DE-2719)2810915$$aMaetzler, Walter$$b3$$udzne
000157807 7001_ $$0P:(DE-2719)2812736$$aWurster, Isabel$$b4$$udzne
000157807 7001_ $$0P:(DE-2719)2813263$$aHayer, Stefanie$$b5$$udzne
000157807 7001_ $$0P:(DE-2719)2814101$$aWilke, Carlo$$b6$$udzne
000157807 7001_ $$0P:(DE-2719)2811940$$aHengel, Holger$$b7$$udzne
000157807 7001_ $$0P:(DE-2719)2812712$$aReichbauer, Jennifer$$b8$$udzne
000157807 7001_ $$aArmbruster, Marcel$$b9
000157807 7001_ $$0P:(DE-2719)2810795$$aSchöls, Ludger$$b10$$udzne
000157807 7001_ $$aMartus, Peter$$b11
000157807 7001_ $$0P:(DE-2719)2812018$$aSchüle-Freyer, Rebecca$$b12$$eLast author$$udzne
000157807 773__ $$0PERI:(DE-600)2740696-9$$a10.1002/acn3.51358$$gVol. 8, no. 5, p. 1122 - 1131$$n5$$p1122 - 1131$$tAnnals of Clinical and Translational Neurology$$v8$$x2328-9503$$y2021
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