TY  - JOUR
AU  - Kessler, Christoph
AU  - Serna-Higuita, Lina M
AU  - Rattay, Tim W
AU  - Maetzler, Walter
AU  - Wurster, Isabel
AU  - Hayer, Stefanie
AU  - Wilke, Carlo
AU  - Hengel, Holger
AU  - Reichbauer, Jennifer
AU  - Armbruster, Marcel
AU  - Schöls, Ludger
AU  - Martus, Peter
AU  - Schüle-Freyer, Rebecca
TI  - Neurofilament light chain is a cerebrospinal fluid biomarker in hereditary spastic paraplegia.
JO  - Annals of Clinical and Translational Neurology
VL  - 8
IS  - 5
SN  - 2328-9503
CY  - Chichester [u.a.]
PB  - Wiley
M1  - DZNE-2021-01264
SP  - 1122 - 1131
PY  - 2021
N1  - CC BY-NC-ND
AB  - Despite the need for diagnostics and research, data on fluid biomarkers in hereditary spastic paraplegia (HSP) are scarce. We, therefore, explore Neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of patients with hereditary spastic paraplegia and provide information on the influence of demographic factors.The study recruited 59 HSP cases (33 genetically confirmed) and 59 controls matched in age and sex. Neurofilament light chain levels were assessed by enzyme-linked immunosorbent assay. The statistical analysis included the effects of age, sex, and genetic status (confirmed vs. not confirmed).Levels of CSF NfL were significantly increased in patients with hereditary spastic paraplegia compared to controls (median 741 pg/mL vs. 387 pg/mL, p < 0.001). Age (1.4
KW  - Adolescent
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Biomarkers: cerebrospinal fluid
KW  - Cross-Sectional Studies
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Neurofilament Proteins: cerebrospinal fluid
KW  - Sex Factors
KW  - Spastic Paraplegia, Hereditary: cerebrospinal fluid
KW  - Spastic Paraplegia, Hereditary: diagnosis
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:33819388
C2  - pmc:PMC8108414
DO  - DOI:10.1002/acn3.51358
UR  - https://pub.dzne.de/record/157807
ER  -